Novel derivatives of bacteriochlorophyll a: Complex formation with albumin and the mechanism of tumor cell photodamage

The goal of this work was to study the formation of complexes by bacteriochlorophyll a derivatives with HSA and the ability of these compounds to initiate the photoinduced death of tumor cells. The high constants of complex formation with albumin, chemical and light stability, the absence of dark cy...

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Published in:Doklady. Biochemistry and biophysics 2014, Vol.454 (1), p.17-20
Main Authors: Akimova, A. V., Grin, M. A., Golovina, G. V., Kokrashvili, T. A., Vinogradov, A. M., Mironov, A. F., Rychkov, G. N., Shtil, A. A., Kuzmin, V. A., Durandin, N. A.
Format: Article
Language:English
Subjects:
Apoptosis
Bacteriochlorophyll A - chemistry
Bacteriochlorophyll A - metabolism
Bacteriochlorophyll A - pharmacology
Bacteriology
Biochemistry
Biological and Medical Physics
Biomedical and Life Sciences
Biophysics
Biophysics and Molecular Biology
Cancer therapies
Cell Death - drug effects
Cell Death - radiation effects
Dose-Response Relationship, Drug
HCT116 Cells
Humans
Life Sciences
Light
Photosensitizing Agents - chemistry
Photosensitizing Agents - metabolism
Photosensitizing Agents - pharmacology
Serum Albumin - metabolism
Tumors
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Summary:The goal of this work was to study the formation of complexes by bacteriochlorophyll a derivatives with HSA and the ability of these compounds to initiate the photoinduced death of tumor cells. The high constants of complex formation with albumin, chemical and light stability, the absence of dark cytotoxicity, and the high efficiency of photo damage of tumor cells suggest that the novel class of cycloimide derivatives of natural bacteriochlorophyll a is promising for the development of anticancer photosensitizers.
ISSN:1607-6729
1608-3091
DOI:10.1134/S1607672914010062