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Novel derivatives of bacteriochlorophyll a: Complex formation with albumin and the mechanism of tumor cell photodamage

The goal of this work was to study the formation of complexes by bacteriochlorophyll a derivatives with HSA and the ability of these compounds to initiate the photoinduced death of tumor cells. The high constants of complex formation with albumin, chemical and light stability, the absence of dark cy...

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Published in:	Doklady. Biochemistry and biophysics 2014, Vol.454 (1), p.17-20
Main Authors:	Akimova, A. V., Grin, M. A., Golovina, G. V., Kokrashvili, T. A., Vinogradov, A. M., Mironov, A. F., Rychkov, G. N., Shtil, A. A., Kuzmin, V. A., Durandin, N. A.
Format:	Article
Language:	English
Subjects:	Apoptosis Bacteriochlorophyll A - chemistry Bacteriochlorophyll A - metabolism Bacteriochlorophyll A - pharmacology Bacteriology Biochemistry Biological and Medical Physics Biomedical and Life Sciences Biophysics Biophysics and Molecular Biology Cancer therapies Cell Death - drug effects Cell Death - radiation effects Dose-Response Relationship, Drug HCT116 Cells Humans Life Sciences Light Photosensitizing Agents - chemistry Photosensitizing Agents - metabolism Photosensitizing Agents - pharmacology Serum Albumin - metabolism Tumors
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description	The goal of this work was to study the formation of complexes by bacteriochlorophyll a derivatives with HSA and the ability of these compounds to initiate the photoinduced death of tumor cells. The high constants of complex formation with albumin, chemical and light stability, the absence of dark cytotoxicity, and the high efficiency of photo damage of tumor cells suggest that the novel class of cycloimide derivatives of natural bacteriochlorophyll a is promising for the development of anticancer photosensitizers.
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V. ; Grin, M. A. ; Golovina, G. V. ; Kokrashvili, T. A. ; Vinogradov, A. M. ; Mironov, A. F. ; Rychkov, G. N. ; Shtil, A. A. ; Kuzmin, V. A. ; Durandin, N. A.</creator><creatorcontrib>Akimova, A. V. ; Grin, M. A. ; Golovina, G. V. ; Kokrashvili, T. A. ; Vinogradov, A. M. ; Mironov, A. F. ; Rychkov, G. N. ; Shtil, A. A. ; Kuzmin, V. A. ; Durandin, N. A.</creatorcontrib><description>The goal of this work was to study the formation of complexes by bacteriochlorophyll a derivatives with HSA and the ability of these compounds to initiate the photoinduced death of tumor cells. The high constants of complex formation with albumin, chemical and light stability, the absence of dark cytotoxicity, and the high efficiency of photo damage of tumor cells suggest that the novel class of cycloimide derivatives of natural bacteriochlorophyll a is promising for the development of anticancer photosensitizers.</description><identifier>ISSN: 1607-6729</identifier><identifier>EISSN: 1608-3091</identifier><identifier>DOI: 10.1134/S1607672914010062</identifier><identifier>PMID: 24633606</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>Apoptosis ; Bacteriochlorophyll A - chemistry ; Bacteriochlorophyll A - metabolism ; Bacteriochlorophyll A - pharmacology ; Bacteriology ; Biochemistry ; Biological and Medical Physics ; Biomedical and Life Sciences ; Biophysics ; Biophysics and Molecular Biology ; Cancer therapies ; Cell Death - drug effects ; Cell Death - radiation effects ; Dose-Response Relationship, Drug ; HCT116 Cells ; Humans ; Life Sciences ; Light ; Photosensitizing Agents - chemistry ; Photosensitizing Agents - metabolism ; Photosensitizing Agents - pharmacology ; Serum Albumin - metabolism ; Tumors</subject><ispartof>Doklady. 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subjects	Apoptosis Bacteriochlorophyll A - chemistry Bacteriochlorophyll A - metabolism Bacteriochlorophyll A - pharmacology Bacteriology Biochemistry Biological and Medical Physics Biomedical and Life Sciences Biophysics Biophysics and Molecular Biology Cancer therapies Cell Death - drug effects Cell Death - radiation effects Dose-Response Relationship, Drug HCT116 Cells Humans Life Sciences Light Photosensitizing Agents - chemistry Photosensitizing Agents - metabolism Photosensitizing Agents - pharmacology Serum Albumin - metabolism Tumors
title	Novel derivatives of bacteriochlorophyll a: Complex formation with albumin and the mechanism of tumor cell photodamage
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