Clinical subtypes in Parkinson’s disease: the impact of MAPT haplotypes

The H1 haplotype of the MAPT gene influences the risk of PD and has been related to the development of PDD. We evaluated the influence of MAPT haplotypes on the expression of motor features in PD patients. We genotyped, for the MAPT haplotypes H1 and H2, a sample of 181 PD patients with distinct cli...

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Bibliographic Details
Published in:Journal of Neural Transmission 2014-04, Vol.121 (4), p.353-356
Main Authors: Di Battista, Maria Elena, Pascale, Esterina, Purcaro, Carlo, Passarelli, Francesca, Passarelli, Emanuela, Guglielmi, Renzo, Vanacore, Nicola, Meco, Giuseppe
Format: Article
Language:English
Subjects:
Aged
DNA Mutational Analysis
Female
Haplotypes
Humans
Male
Medicine
Medicine & Public Health
Middle Aged
Neurology
Neurology and Preclinical Neurological Studies - Short communication
Neurosciences
Parkinson Disease - classification
Parkinson Disease - complications
Parkinson Disease - genetics
Parkinson's disease
Psychiatry
Regression Analysis
Severity of Illness Index
tau Proteins - genetics
Tremor - etiology
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Summary:The H1 haplotype of the MAPT gene influences the risk of PD and has been related to the development of PDD. We evaluated the influence of MAPT haplotypes on the expression of motor features in PD patients. We genotyped, for the MAPT haplotypes H1 and H2, a sample of 181 PD patients with distinct clinical subtypes: tremor dominant and non-tremor dominant (NTD). Our results indicate that the MAPT haplotypes contribute to the expression of motor features of PD. H1 homozygous PD patients are significantly more likely to present a NTD phenotype, a clinical subtype characterized by widespread pathological degeneration, than H2 carriers.
ISSN:0300-9564
1435-1463
DOI:10.1007/s00702-013-1117-7