Biocompatibility of Modified Bionanocellulose and Porous Poly((...)-caprolactone) Biomaterials

Biocompatibility of modified bionanocellulose (BC) and porous poly(... caprolactone) (PCL) were compared to UHMWPE. For all the materials lack of cytotoxic effect to mouse fibroblasts was observed in vitro. In vivo study, subcutaneous implantations in Wistar rats, lasted for seven, 14, and 30 days....

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Bibliographic Details
Published in:International journal of polymeric materials 2014-07, Vol.63 (10), p.518
Main Authors: Grobelski, Bartlomiej, Wach, Radoslaw A, Adamus, Agnieszka, Olejnik, Alicja K, Kowalska-Ludwicka, Karolina, Kolodziejczyk, Marek, Bielecki, Stanislaw, Rosiak, Janusz M, Pasieka, Zbigniew
Format: Article
Language:English
Subjects:
Cellulose
Cytotoxicity
Lymphocytes
Porosity
Rodents
Tissues
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Summary:Biocompatibility of modified bionanocellulose (BC) and porous poly(... caprolactone) (PCL) were compared to UHMWPE. For all the materials lack of cytotoxic effect to mouse fibroblasts was observed in vitro. In vivo study, subcutaneous implantations in Wistar rats, lasted for seven, 14, and 30 days. Subsequently the composition of surrounding tissue and explants surface changes was evaluated. No symptoms of acute inflammation were observed. Surrounding tissue thickness, the number of granulocytes, lymphocytes, macrophages, and blood vessels differed in time and revealed regular healing process. It is concluded that investigated PCL and BC are the materials with superior biocompatibility with high application potential. (ProQuest: ... denotes formulae/symbols omitted.)
ISSN:0091-4037
1563-535X