TRIENNIAL GROWTH SYMPOSIUM— Novel roles for vitamin D in animal immunity and health1

Recent years have seen significant advances in the generation, validation, and implementation of nutritional supplements for food production animals. Examination of their impact on animal performance and health requires collaboration among animal scientists, nutritionists, biochemists, immunologists...

Full description

Saved in:
Bibliographic Details
Published in:Journal of animal science 2014-03, Vol.92 (3), p.930-938
Main Authors: Barreda, D. R., Konowalchuk, J. D., Rieger, A. M., Wong, M. E., Havixbeck, J. J.
Format: Article
Language:English
Subjects:
Animal sciences
Dietary supplements
Hogs
Immunity (Disease)
Leukocytes
Vitamin D
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Recent years have seen significant advances in the generation, validation, and implementation of nutritional supplements for food production animals. Examination of their impact on animal performance and health requires collaboration among animal scientists, nutritionists, biochemists, immunologists, veterinarians, and others. Each provides a unique perspective on the mechanisms of action, short and longterm impacts, and most effective strategies for implementation into continuously evolving industrial practices. In this review we provide a comparative immunology perspective on the impact of vitamin D on animal performance and health, describe the differential contributions of vitamin D^sub 3^ and of a commercial hydroxylated version of vitamin D^sub 3^, 25-hydroxyvitamin D^sub 3^ (25(OH) D^sub 3^ or HyD) to swine immunity, and highlight recent advances in the technologies that can be used to dissect the cellular and molecular mechanisms that impact production animal immunity and health. Among others, we pay particular attention to how these novel approaches help decrease the variability often observed in immuneassociated datasets. From a practical perspective, this is critical for evaluation of in vivo effects for this nutritional supplement as small but meaningful changes to specific immune responses are typical under normal physiological conditions. Furthermore, as the range of reagents and technologies expands for comparative animal models, it is imperative that continued efforts are placed on the capacity to compare results across different experimental platforms. [PUBLICATION ABSTRACT]
ISSN:0021-8812
1525-3163
DOI:10.2527/jas.2013-7341