Anti-angiogenic effect of Tanshinone IIA involves inhibition of matrix invasion and modification of MMP-2/TIMP-2 secretion in vascular endothelial cells

• Published in: Cancer letters 2011-11, Vol.310 (2), p.198-206
• Main Authors: Tsai, Ming-Yen, Yang, Rong-Chi, Wu, Hsiao-Ting, Pang, Jong-Hwei S, Huang, Sheng-Teng
• Format: Article
• Language: English
• Subjects: Angiogenesis; Angiogenesis Inhibitors - pharmacology; Animals; anticarcinogenic activity; Cancer; Cell adhesion & migration; Cell culture; Cell Movement - drug effects; Chick chorioallantoic membrane assay; Chick Embryo; chickens; chorioallantoic membrane; Chorioallantoic Membrane - blood supply; cytosol; Diterpenes, Abietane - pharmacology; endothelial cells; Endothelial Cells - cytology; Endothelial Cells - drug effects; Endothelial Cells - metabolism; extracellular matrix; gelatin; gelatinase A; GPI-Linked Proteins - metabolism; Hematology, Oncology and Palliative Medicine; Human vascular endothelial cells; Humans; Matrix Metalloproteinase 2 - genetics; Matrix Metalloproteinase 2 - metabolism; MMP-2; Neovascularization, Physiologic - drug effects; Proteins; reverse transcriptase polymerase chain reaction; RNA, Messenger - biosynthesis; RNA, Messenger - genetics; Salvia miltiorrhiza; secretion; Tanshinone IIA; TIMP-2; Tissue Inhibitor of Metalloproteinase-2 - genetics; Tissue Inhibitor of Metalloproteinase-2 - metabolism; Tumor Necrosis Factor-alpha - antagonists & inhibitors; Tumor Necrosis Factor-alpha - pharmacology; Western blotting
• ISSN: 0304-3835; 1872-7980
• DOI: 10.1016/j.canlet.2011.06.031

Highlights ► Tanshinone IIA (Tan IIA) inhibited both in vivo and in vitro angiogenesis. ► Tan IIA could modulate the MMP-2 activity and the MMP-2/TIMP-2 secretion. ► MMPs play a key role in the angiogenic process. ► Tanshinone IIA might be a potential to develop anti-cancer agent.