Loading…
Anti-angiogenic effect of Tanshinone IIA involves inhibition of matrix invasion and modification of MMP-2/TIMP-2 secretion in vascular endothelial cells
Highlights ► Tanshinone IIA (Tan IIA) inhibited both in vivo and in vitro angiogenesis. ► Tan IIA could modulate the MMP-2 activity and the MMP-2/TIMP-2 secretion. ► MMPs play a key role in the angiogenic process. ► Tanshinone IIA might be a potential to develop anti-cancer agent.
Saved in:
| Published in: | Cancer letters 2011-11, Vol.310 (2), p.198-206 |
|---|---|
| Main Authors: | , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c534t-59c94883c961a1e69d91bfae93a4965beb35f1b74a4cc6e817c00b5924c8692f3 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c534t-59c94883c961a1e69d91bfae93a4965beb35f1b74a4cc6e817c00b5924c8692f3 |
| container_end_page | 206 |
| container_issue | 2 |
| container_start_page | 198 |
| container_title | Cancer letters |
| container_volume | 310 |
| creator | Tsai, Ming-Yen Yang, Rong-Chi Wu, Hsiao-Ting Pang, Jong-Hwei S Huang, Sheng-Teng |
| description | Highlights ► Tanshinone IIA (Tan IIA) inhibited both in vivo and in vitro angiogenesis. ► Tan IIA could modulate the MMP-2 activity and the MMP-2/TIMP-2 secretion. ► MMPs play a key role in the angiogenic process. ► Tanshinone IIA might be a potential to develop anti-cancer agent. |
| doi_str_mv | 10.1016/j.canlet.2011.06.031 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_1512601640</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0304383511003880</els_id><sourcerecordid>3265825401</sourcerecordid><originalsourceid>FETCH-LOGICAL-c534t-59c94883c961a1e69d91bfae93a4965beb35f1b74a4cc6e817c00b5924c8692f3</originalsourceid><addsrcrecordid>eNqFks9uEzEQxi0EoqHwBggscd6tvbZ3vRekqOJPpFYgNT1bXu84cXDsYm8i-iY8Ll7SgsSF01ie33wezzcIvaakpoS2F7va6OBhqhtCaU3amjD6BC2o7Jqq6yV5ihaEEV4xycQZepHzjhAieCeeo7OGdlJS0izQz2WYXKXDxsUNBGcwWAtmwtHitQ5560IMgFerJXbhGP0Rcjls3eAmF8NM7fWU3I85q_N8pcOI93F01hn9yFxff62ai_VqDjiDSfA74wIuRebgdcIQxjhtwTvtsQHv80v0zGqf4dVDPEe3Hz-sLz9XV18-rS6XV5URjE-V6E3PpWSmb6mm0PZjTweroWea960YYGDC0qHjmhvTgqSdIWQQfcONbPvGsnP07qR7l-L3A-RJ7eIhhfKkooI2bRk1J4XiJ8qkmHMCq-6S2-t0ryhRsx1qp052qNkORVpV7Chlbx7ED8Mexj9Fj_MvwNsTYHVUepNcVrc3RUEUr1jTSVGI9ycCyhCODpLKxkEwMLpUjFJjdP_r4V8B411xWvtvcA_5729VbhRRN_PSzDtDaWlBSsJ-AZKFvCw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1512601640</pqid></control><display><type>article</type><title>Anti-angiogenic effect of Tanshinone IIA involves inhibition of matrix invasion and modification of MMP-2/TIMP-2 secretion in vascular endothelial cells</title><source>ScienceDirect Journals</source><creator>Tsai, Ming-Yen ; Yang, Rong-Chi ; Wu, Hsiao-Ting ; Pang, Jong-Hwei S ; Huang, Sheng-Teng</creator><creatorcontrib>Tsai, Ming-Yen ; Yang, Rong-Chi ; Wu, Hsiao-Ting ; Pang, Jong-Hwei S ; Huang, Sheng-Teng</creatorcontrib><description>Highlights ► Tanshinone IIA (Tan IIA) inhibited both in vivo and in vitro angiogenesis. ► Tan IIA could modulate the MMP-2 activity and the MMP-2/TIMP-2 secretion. ► MMPs play a key role in the angiogenic process. ► Tanshinone IIA might be a potential to develop anti-cancer agent.</description><identifier>ISSN: 0304-3835</identifier><identifier>EISSN: 1872-7980</identifier><identifier>DOI: 10.1016/j.canlet.2011.06.031</identifier><identifier>PMID: 21788102</identifier><language>eng</language><publisher>Ireland: Elsevier Ireland Ltd</publisher><subject>Angiogenesis ; Angiogenesis Inhibitors - pharmacology ; Animals ; anticarcinogenic activity ; Cancer ; Cell adhesion & migration ; Cell culture ; Cell Movement - drug effects ; Chick chorioallantoic membrane assay ; Chick Embryo ; chickens ; chorioallantoic membrane ; Chorioallantoic Membrane - blood supply ; cytosol ; Diterpenes, Abietane - pharmacology ; endothelial cells ; Endothelial Cells - cytology ; Endothelial Cells - drug effects ; Endothelial Cells - metabolism ; extracellular matrix ; gelatin ; gelatinase A ; GPI-Linked Proteins - metabolism ; Hematology, Oncology and Palliative Medicine ; Human vascular endothelial cells ; Humans ; Matrix Metalloproteinase 2 - genetics ; Matrix Metalloproteinase 2 - metabolism ; MMP-2 ; Neovascularization, Physiologic - drug effects ; Proteins ; reverse transcriptase polymerase chain reaction ; RNA, Messenger - biosynthesis ; RNA, Messenger - genetics ; Salvia miltiorrhiza ; secretion ; Tanshinone IIA ; TIMP-2 ; Tissue Inhibitor of Metalloproteinase-2 - genetics ; Tissue Inhibitor of Metalloproteinase-2 - metabolism ; Tumor Necrosis Factor-alpha - antagonists & inhibitors ; Tumor Necrosis Factor-alpha - pharmacology ; Western blotting</subject><ispartof>Cancer letters, 2011-11, Vol.310 (2), p.198-206</ispartof><rights>Elsevier Ireland Ltd</rights><rights>2011 Elsevier Ireland Ltd</rights><rights>Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.</rights><rights>Copyright Elsevier Limited Nov 28, 2011</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c534t-59c94883c961a1e69d91bfae93a4965beb35f1b74a4cc6e817c00b5924c8692f3</citedby><cites>FETCH-LOGICAL-c534t-59c94883c961a1e69d91bfae93a4965beb35f1b74a4cc6e817c00b5924c8692f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21788102$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tsai, Ming-Yen</creatorcontrib><creatorcontrib>Yang, Rong-Chi</creatorcontrib><creatorcontrib>Wu, Hsiao-Ting</creatorcontrib><creatorcontrib>Pang, Jong-Hwei S</creatorcontrib><creatorcontrib>Huang, Sheng-Teng</creatorcontrib><title>Anti-angiogenic effect of Tanshinone IIA involves inhibition of matrix invasion and modification of MMP-2/TIMP-2 secretion in vascular endothelial cells</title><title>Cancer letters</title><addtitle>Cancer Lett</addtitle><description>Highlights ► Tanshinone IIA (Tan IIA) inhibited both in vivo and in vitro angiogenesis. ► Tan IIA could modulate the MMP-2 activity and the MMP-2/TIMP-2 secretion. ► MMPs play a key role in the angiogenic process. ► Tanshinone IIA might be a potential to develop anti-cancer agent.</description><subject>Angiogenesis</subject><subject>Angiogenesis Inhibitors - pharmacology</subject><subject>Animals</subject><subject>anticarcinogenic activity</subject><subject>Cancer</subject><subject>Cell adhesion & migration</subject><subject>Cell culture</subject><subject>Cell Movement - drug effects</subject><subject>Chick chorioallantoic membrane assay</subject><subject>Chick Embryo</subject><subject>chickens</subject><subject>chorioallantoic membrane</subject><subject>Chorioallantoic Membrane - blood supply</subject><subject>cytosol</subject><subject>Diterpenes, Abietane - pharmacology</subject><subject>endothelial cells</subject><subject>Endothelial Cells - cytology</subject><subject>Endothelial Cells - drug effects</subject><subject>Endothelial Cells - metabolism</subject><subject>extracellular matrix</subject><subject>gelatin</subject><subject>gelatinase A</subject><subject>GPI-Linked Proteins - metabolism</subject><subject>Hematology, Oncology and Palliative Medicine</subject><subject>Human vascular endothelial cells</subject><subject>Humans</subject><subject>Matrix Metalloproteinase 2 - genetics</subject><subject>Matrix Metalloproteinase 2 - metabolism</subject><subject>MMP-2</subject><subject>Neovascularization, Physiologic - drug effects</subject><subject>Proteins</subject><subject>reverse transcriptase polymerase chain reaction</subject><subject>RNA, Messenger - biosynthesis</subject><subject>RNA, Messenger - genetics</subject><subject>Salvia miltiorrhiza</subject><subject>secretion</subject><subject>Tanshinone IIA</subject><subject>TIMP-2</subject><subject>Tissue Inhibitor of Metalloproteinase-2 - genetics</subject><subject>Tissue Inhibitor of Metalloproteinase-2 - metabolism</subject><subject>Tumor Necrosis Factor-alpha - antagonists & inhibitors</subject><subject>Tumor Necrosis Factor-alpha - pharmacology</subject><subject>Western blotting</subject><issn>0304-3835</issn><issn>1872-7980</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><recordid>eNqFks9uEzEQxi0EoqHwBggscd6tvbZ3vRekqOJPpFYgNT1bXu84cXDsYm8i-iY8Ll7SgsSF01ie33wezzcIvaakpoS2F7va6OBhqhtCaU3amjD6BC2o7Jqq6yV5ihaEEV4xycQZepHzjhAieCeeo7OGdlJS0izQz2WYXKXDxsUNBGcwWAtmwtHitQ5560IMgFerJXbhGP0Rcjls3eAmF8NM7fWU3I85q_N8pcOI93F01hn9yFxff62ai_VqDjiDSfA74wIuRebgdcIQxjhtwTvtsQHv80v0zGqf4dVDPEe3Hz-sLz9XV18-rS6XV5URjE-V6E3PpWSmb6mm0PZjTweroWea960YYGDC0qHjmhvTgqSdIWQQfcONbPvGsnP07qR7l-L3A-RJ7eIhhfKkooI2bRk1J4XiJ8qkmHMCq-6S2-t0ryhRsx1qp052qNkORVpV7Chlbx7ED8Mexj9Fj_MvwNsTYHVUepNcVrc3RUEUr1jTSVGI9ycCyhCODpLKxkEwMLpUjFJjdP_r4V8B411xWvtvcA_5729VbhRRN_PSzDtDaWlBSsJ-AZKFvCw</recordid><startdate>20111128</startdate><enddate>20111128</enddate><creator>Tsai, Ming-Yen</creator><creator>Yang, Rong-Chi</creator><creator>Wu, Hsiao-Ting</creator><creator>Pang, Jong-Hwei S</creator><creator>Huang, Sheng-Teng</creator><general>Elsevier Ireland Ltd</general><general>Elsevier Limited</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TO</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope></search><sort><creationdate>20111128</creationdate><title>Anti-angiogenic effect of Tanshinone IIA involves inhibition of matrix invasion and modification of MMP-2/TIMP-2 secretion in vascular endothelial cells</title><author>Tsai, Ming-Yen ; Yang, Rong-Chi ; Wu, Hsiao-Ting ; Pang, Jong-Hwei S ; Huang, Sheng-Teng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c534t-59c94883c961a1e69d91bfae93a4965beb35f1b74a4cc6e817c00b5924c8692f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Angiogenesis</topic><topic>Angiogenesis Inhibitors - pharmacology</topic><topic>Animals</topic><topic>anticarcinogenic activity</topic><topic>Cancer</topic><topic>Cell adhesion & migration</topic><topic>Cell culture</topic><topic>Cell Movement - drug effects</topic><topic>Chick chorioallantoic membrane assay</topic><topic>Chick Embryo</topic><topic>chickens</topic><topic>chorioallantoic membrane</topic><topic>Chorioallantoic Membrane - blood supply</topic><topic>cytosol</topic><topic>Diterpenes, Abietane - pharmacology</topic><topic>endothelial cells</topic><topic>Endothelial Cells - cytology</topic><topic>Endothelial Cells - drug effects</topic><topic>Endothelial Cells - metabolism</topic><topic>extracellular matrix</topic><topic>gelatin</topic><topic>gelatinase A</topic><topic>GPI-Linked Proteins - metabolism</topic><topic>Hematology, Oncology and Palliative Medicine</topic><topic>Human vascular endothelial cells</topic><topic>Humans</topic><topic>Matrix Metalloproteinase 2 - genetics</topic><topic>Matrix Metalloproteinase 2 - metabolism</topic><topic>MMP-2</topic><topic>Neovascularization, Physiologic - drug effects</topic><topic>Proteins</topic><topic>reverse transcriptase polymerase chain reaction</topic><topic>RNA, Messenger - biosynthesis</topic><topic>RNA, Messenger - genetics</topic><topic>Salvia miltiorrhiza</topic><topic>secretion</topic><topic>Tanshinone IIA</topic><topic>TIMP-2</topic><topic>Tissue Inhibitor of Metalloproteinase-2 - genetics</topic><topic>Tissue Inhibitor of Metalloproteinase-2 - metabolism</topic><topic>Tumor Necrosis Factor-alpha - antagonists & inhibitors</topic><topic>Tumor Necrosis Factor-alpha - pharmacology</topic><topic>Western blotting</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tsai, Ming-Yen</creatorcontrib><creatorcontrib>Yang, Rong-Chi</creatorcontrib><creatorcontrib>Wu, Hsiao-Ting</creatorcontrib><creatorcontrib>Pang, Jong-Hwei S</creatorcontrib><creatorcontrib>Huang, Sheng-Teng</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><jtitle>Cancer letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tsai, Ming-Yen</au><au>Yang, Rong-Chi</au><au>Wu, Hsiao-Ting</au><au>Pang, Jong-Hwei S</au><au>Huang, Sheng-Teng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Anti-angiogenic effect of Tanshinone IIA involves inhibition of matrix invasion and modification of MMP-2/TIMP-2 secretion in vascular endothelial cells</atitle><jtitle>Cancer letters</jtitle><addtitle>Cancer Lett</addtitle><date>2011-11-28</date><risdate>2011</risdate><volume>310</volume><issue>2</issue><spage>198</spage><epage>206</epage><pages>198-206</pages><issn>0304-3835</issn><eissn>1872-7980</eissn><abstract>Highlights ► Tanshinone IIA (Tan IIA) inhibited both in vivo and in vitro angiogenesis. ► Tan IIA could modulate the MMP-2 activity and the MMP-2/TIMP-2 secretion. ► MMPs play a key role in the angiogenic process. ► Tanshinone IIA might be a potential to develop anti-cancer agent.</abstract><cop>Ireland</cop><pub>Elsevier Ireland Ltd</pub><pmid>21788102</pmid><doi>10.1016/j.canlet.2011.06.031</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0304-3835 |
| ispartof | Cancer letters, 2011-11, Vol.310 (2), p.198-206 |
| issn | 0304-3835 1872-7980 |
| language | eng |
| recordid | cdi_proquest_journals_1512601640 |
| source | ScienceDirect Journals |
| subjects | Angiogenesis Angiogenesis Inhibitors - pharmacology Animals anticarcinogenic activity Cancer Cell adhesion & migration Cell culture Cell Movement - drug effects Chick chorioallantoic membrane assay Chick Embryo chickens chorioallantoic membrane Chorioallantoic Membrane - blood supply cytosol Diterpenes, Abietane - pharmacology endothelial cells Endothelial Cells - cytology Endothelial Cells - drug effects Endothelial Cells - metabolism extracellular matrix gelatin gelatinase A GPI-Linked Proteins - metabolism Hematology, Oncology and Palliative Medicine Human vascular endothelial cells Humans Matrix Metalloproteinase 2 - genetics Matrix Metalloproteinase 2 - metabolism MMP-2 Neovascularization, Physiologic - drug effects Proteins reverse transcriptase polymerase chain reaction RNA, Messenger - biosynthesis RNA, Messenger - genetics Salvia miltiorrhiza secretion Tanshinone IIA TIMP-2 Tissue Inhibitor of Metalloproteinase-2 - genetics Tissue Inhibitor of Metalloproteinase-2 - metabolism Tumor Necrosis Factor-alpha - antagonists & inhibitors Tumor Necrosis Factor-alpha - pharmacology Western blotting |
| title | Anti-angiogenic effect of Tanshinone IIA involves inhibition of matrix invasion and modification of MMP-2/TIMP-2 secretion in vascular endothelial cells |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-29T10%3A00%3A56IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Anti-angiogenic%20effect%20of%20Tanshinone%20IIA%20involves%20inhibition%20of%20matrix%20invasion%20and%20modification%20of%20MMP-2/TIMP-2%20secretion%20in%20vascular%20endothelial%20cells&rft.jtitle=Cancer%20letters&rft.au=Tsai,%20Ming-Yen&rft.date=2011-11-28&rft.volume=310&rft.issue=2&rft.spage=198&rft.epage=206&rft.pages=198-206&rft.issn=0304-3835&rft.eissn=1872-7980&rft_id=info:doi/10.1016/j.canlet.2011.06.031&rft_dat=%3Cproquest_cross%3E3265825401%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c534t-59c94883c961a1e69d91bfae93a4965beb35f1b74a4cc6e817c00b5924c8692f3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1512601640&rft_id=info:pmid/21788102&rfr_iscdi=true |