Detection of Helicobacter Pylori Infection in Egyptian patients with chronic calcular cholecystitis

Reports of Helicobacter pylori in biliary tract diseases in humans are very fragmentary, and therefore there is a need for further investigations. This study aims to detect H. pylori in the bile and gall bladder (GB) of patients with chronic calcular cholecystitis (CCC), and to determine the associa...

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Bibliographic Details
Published in:British journal of biomedical science 2014-01, Vol.71 (1), p.13-18
Main Authors: Helaly, G. F., El-Ghazzawi, E. F., Kazeiw, A.H., Dowidar, N. L., Anwar, M. M., Attia, N. M.
Format: Article
Language:English
Subjects:
Adult
Bile - microbiology
Biopsy
Cholecystitis
Cholecystitis - microbiology
Chronic Disease
Egypt
Female
Gallbladder
Gallbladder - microbiology
Gallbladder diseases
Helicobacter Infections - diagnosis
Helicobacter pylori
Helicobacter pylori - isolation & purification
Histopathology
Humans
Immunohistochemistry
Infections
Pathogenesis
Pathology
Patients
Statistical analysis
Ulcers
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Summary:Reports of Helicobacter pylori in biliary tract diseases in humans are very fragmentary, and therefore there is a need for further investigations. This study aims to detect H. pylori in the bile and gall bladder (GB) of patients with chronic calcular cholecystitis (CCC), and to determine the association of H. pylori infection with gallstone type. Thirty patients with CCC admitted for laparoscopic cholecystectomy were investigated, including upper gastro-endoscopy before cholecystectomy. Rapid urease test and histopathological examination were performed on gastric biopsies. The GB specimens were investigated for the presence of H. pylori by immunohistochemistry (IHC). H. pylori antigen in bile was detected by enzyme immunoassay. Chemical analysis of gallstones was performed to determine type. Immunohistochemistry testing showed 73.3 % and 66.7% positivity among GB neck and body biopsies, respectively, demonstrating high sensitivity and specificity. A significant association was found between gastric and GB H. pylori positivity (P
ISSN:0967-4845
2474-0896
DOI:10.1080/09674845.2014.11669957