Resveratrol inhibits the epidermal growth factor-induced epithelial mesenchymal transition in MCF-7 cells

• Published in: Cancer letters 2011-11, Vol.310 (1), p.1-8
• Main Authors: Vergara, Daniele, Valente, Concetta Maria, Tinelli, Andrea, Siciliano, Carlo, Lorusso, Vito, Acierno, Raffaele, Giovinazzo, Giovanna, Santino, Angelo, Storelli, Carlo, Maffia, Michele
• Format: Article
• Language: English
• Subjects: Actin Depolymerizing Factors - metabolism; Angiogenesis Inhibitors - pharmacology; Breast cancer; Breast Neoplasms - genetics; Breast Neoplasms - metabolism; Breast Neoplasms - pathology; Butadienes - pharmacology; Cadherins - genetics; carcinoma; cell biology; Cell Line, Tumor; Cell Movement - drug effects; Cell Proliferation - drug effects; Cell Shape - drug effects; Cell Survival - drug effects; chemical inhibitors; EGF; Enzyme Inhibitors - pharmacology; Epidermal growth factor; Epidermal Growth Factor - pharmacology; Epithelial-Mesenchymal Transition - drug effects; Epithelial-Mesenchymal Transition - genetics; Epithelial–mesenchymal transition; gene expression regulation; Gene Expression Regulation, Neoplastic - drug effects; Hematology, Oncology and Palliative Medicine; Homeodomain Proteins - genetics; Humans; Immunoblotting; MCF-7; mitogen-activated protein kinase; Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors; Mitogen-Activated Protein Kinase 1 - metabolism; Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors; Mitogen-Activated Protein Kinase 3 - metabolism; Nitriles - pharmacology; phenotype; Phosphorylation - drug effects; Repressor Proteins - genetics; Resveratrol; Reverse Transcriptase Polymerase Chain Reaction; Snail Family Transcription Factors; Stilbenes - pharmacology; Studies; transcription factors; Transcription Factors - genetics; vimentin; Vimentin - genetics; Zinc Finger E-box Binding Homeobox 2; Zinc Finger E-box-Binding Homeobox 1
• ISSN: 0304-3835; 1872-7980
• DOI: 10.1016/j.canlet.2011.04.009

Highlights ► We show that EGF promotes epithelial–mesenchymal transition in the MCF-7 breast cancer cell line. ► The phenotypic effects are accompanied by enhanced migration and upregulation of mesenchymal markers. ► Resveratrol is able to inhibit EGF-induced EMT process in MCF-7 cells. ► Inhibition of ERK 1/2 activation by resveratrol is critical to block EMT modifications. ► These findings can support a possible role for resveratrol in the chemoprevention of invasive carcinomas.