A Fluorescent Probe for Fast and Quantitative Detection of Hydrogen Sulfide in Blood

The dose makes the poison: Hydrogen sulfide is an important gasotransmitter for which rapid detection agents are needed. A hydrogen sulfide probe, which allows for fast (within seconds), selective, and quantitative detection in buffer solution, serum, and whole blood is designed, synthesized, and us...

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2011-10, Vol.50 (41), p.9672-9675
Main Authors: Peng, Hanjing, Cheng, Yunfeng, Dai, Chaofeng, King, Adrienne L., Predmore, Benjamin L., Lefer, David J., Wang, Binghe
Format: Article
Language:English
Subjects:
analytical methods
Animals
azides
Dansyl Compounds - chemistry
Fluorescent Dyes - chemistry
Fluorescent Dyes - metabolism
fluorescent probes
Hydrogen sulfide
Hydrogen Sulfide - blood
Indicators and Reagents - chemistry
Mice
Mice, Inbred C57BL
Molecular Structure
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Summary:The dose makes the poison: Hydrogen sulfide is an important gasotransmitter for which rapid detection agents are needed. A hydrogen sulfide probe, which allows for fast (within seconds), selective, and quantitative detection in buffer solution, serum, and whole blood is designed, synthesized, and used for detection of hydrogen sulfide (see picture).
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201104236