Expeditious Synthesis of Tetrasubstituted Helical Alkenes by a Cascade of Palladium-Catalyzed CH Activations

Twisted molecules: A modular approach for the synthesis of tetrasubstituted helical alkenes by a palladium-catalyzed norbornene-mediated domino reaction is presented. This intermolecular domino process allows the formation of three C-C bonds in one operation through a C-H activation/carbopalladation...

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2012-09, Vol.51 (39), p.9846
Main Authors: Liu, Hongqiang, El-Salfiti, Mohamed, Lautens, Mark
Format: Article
Language:English
Online Access:Get full text
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Summary:Twisted molecules: A modular approach for the synthesis of tetrasubstituted helical alkenes by a palladium-catalyzed norbornene-mediated domino reaction is presented. This intermolecular domino process allows the formation of three C-C bonds in one operation through a C-H activation/carbopalladation/C-H activation sequence.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201204226