Helminth-Associated Systemic Immune Activation and HIV Co-receptor Expression: Response to Albendazole/Praziquantel Treatment: e2755

Background It has been hypothesized that helminth infections increase HIV susceptibility by enhancing systemic immune activation and hence contribute to elevated HIV-1 transmission in sub-Saharan Africa. Objective To study systemic immune activation and HIV-1 co-receptor expression in relation to di...

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Bibliographic Details
Published in:PLoS neglected tropical diseases 2014-03, Vol.8 (3)
Main Authors: Chachage, Mkunde, Podola, Lilli, Clowes, Petra, Nsojo, Anthony, Bauer, Asli, Mgaya, Onesmo, Kowour, Dickens, Froeschl, Guenter, Maboko, Leonard, Hoelscher, Michael, Saathoff, Elmar, Geldmacher, Christof
Format: Article
Language:English
Subjects:
Cell differentiation
HIV
Human immunodeficiency virus
Immune system
Studies
T cell receptors
Tropical diseases
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Summary:Background It has been hypothesized that helminth infections increase HIV susceptibility by enhancing systemic immune activation and hence contribute to elevated HIV-1 transmission in sub-Saharan Africa. Objective To study systemic immune activation and HIV-1 co-receptor expression in relation to different helminth infections and in response to helminth treatment. Methods HIV-negative adults with (n = 189) or without (n = 57) different helminth infections, as diagnosed by Kato-Katz, were enrolled in Mbeya, Tanzania. Blinded to helminth infection status, T cell differentiation (CD45RO, CD27), activation (HLA-DR, CD38) and CCR5 expression was determined at baseline and 3 months after Albendazole/Praziquantel treatment. Plasma cytokine levels were compared using a cytometric bead array. Results Trichuris and Ascaris infections were linked to increased frequencies of "activated" CD4 and/or CD8 T cells (p
ISSN:1935-2727
1935-2735
DOI:10.1371/journal.pntd.0002755