Cover Picture: Eur. J. Immunol. 2/11

The cover image of this issue consists of the immunohistochemical staining of μ‐calpain in a healthy human kidney and is taken from Letavernier et al. (pp. 473–484). In this article, the authors analyse the role of calpains in acute allograft rejection. The authors demonstrate that μ‐calpain express...

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Bibliographic Details
Published in:European journal of immunology 2011-02, Vol.41 (2), p.n/a
Main Authors: Letavernier, Emmanuel, Dansou, Boris, Lochner, Matthias, Perez, Joëlle, Bellocq, Agnès, Lindenmeyer, Maja T., Cohen, Clemens D., Haymann, Jean‐Philippe, Eberl, Gérard, Baud, Laurent
Format: Article
Language:English
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Summary:The cover image of this issue consists of the immunohistochemical staining of μ‐calpain in a healthy human kidney and is taken from Letavernier et al. (pp. 473–484). In this article, the authors analyse the role of calpains in acute allograft rejection. The authors demonstrate that μ‐calpain expression is increased in human transplant kidneys undergoing acute or chronic rejection, mainly in infiltrating T cells. The authors further show that calpain inhibition delays allograft rejection. Interestingly, this delay in allograft rejection is associated with a limitation in allograft infiltration by T cells that is due to the slowing down in T‐cell migration rather than proliferation.
ISSN:0014-2980
1521-4141
DOI:10.1002/eji.201190003