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Cover Picture: Eur. J. Immunol. 2/11
The cover image of this issue consists of the immunohistochemical staining of μ‐calpain in a healthy human kidney and is taken from Letavernier et al. (pp. 473–484). In this article, the authors analyse the role of calpains in acute allograft rejection. The authors demonstrate that μ‐calpain express...
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| Published in: | European journal of immunology 2011-02, Vol.41 (2), p.n/a |
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| Main Authors: | , , , , , , , , , |
| Format: | Article |
| Language: | English |
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| container_issue | 2 |
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| container_title | European journal of immunology |
| container_volume | 41 |
| creator | Letavernier, Emmanuel Dansou, Boris Lochner, Matthias Perez, Joëlle Bellocq, Agnès Lindenmeyer, Maja T. Cohen, Clemens D. Haymann, Jean‐Philippe Eberl, Gérard Baud, Laurent |
| description | The cover image of this issue consists of the immunohistochemical staining of μ‐calpain in a healthy human kidney and is taken from Letavernier et al. (pp. 473–484). In this article, the authors analyse the role of calpains in acute allograft rejection. The authors demonstrate that μ‐calpain expression is increased in human transplant kidneys undergoing acute or chronic rejection, mainly in infiltrating T cells. The authors further show that calpain inhibition delays allograft rejection. Interestingly, this delay in allograft rejection is associated with a limitation in allograft infiltration by T cells that is due to the slowing down in T‐cell migration rather than proliferation. |
| doi_str_mv | 10.1002/eji.201190003 |
| format | article |
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| title | Cover Picture: Eur. J. Immunol. 2/11 |
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