Copper-Catalyzed Domino Reaction Involving C-C Bond Cleavage To Construct 2-Aryl Quinazolinones

A copper‐catalyzed approach for the synthesis of 2‐aryl‐quinazolinones through a domino reaction involving C–C bond cleavage is described. This protocol involves intramolecular C–C bond cleavage to construct 2‐aryl‐quinazolinones, which may offer an alternative method to prepare medically important...

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Bibliographic Details
Published in:European journal of organic chemistry 2014-05, Vol.2014 (13), p.2682-2685
Main Authors: Wang, Li-Xia, Xiang, Jun-Feng, Tang, Ya-Lin
Format: Article
Language:English
Subjects:
Cleavage reactions
Copper
Domino reactions
Nitrogen heterocycles
Synthetic methods
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Summary:A copper‐catalyzed approach for the synthesis of 2‐aryl‐quinazolinones through a domino reaction involving C–C bond cleavage is described. This protocol involves intramolecular C–C bond cleavage to construct 2‐aryl‐quinazolinones, which may offer an alternative method to prepare medically important quinazolinone derivatives and a new strategy for C–C bond cleavage. Besides C–C bond cleavage, this domino reaction includes N‐arylation and benzylic C–H amidation. A copper‐catalyzed approach for the synthesis of 2‐aryl‐quinazolinones through a domino reaction involving C–C bond cleavage is described. This transformation offers an alternative method to prepare medically important quinazolinone derivatives and a new strategy for C–C bond cleavage.
ISSN:1434-193X
1099-0690
DOI:10.1002/ejoc.201400108