Effects of daidzein and kiwifruit on bone mineral density and equol production in ovariectomised rats

Abstract In this study, we investigated the synergistic effects of daidzein (Dz) and kiwifruit on bone and equol production in ovariectomised (OVX) rats. Female Sprague-Dawley rats were randomly assigned to one of five groups: sham operated, OVX control, OVX fed 0.1% Dz-supplemented diet (OVX + Dz),...

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Bibliographic Details
Published in:International journal of food sciences and nutrition 2014-05, Vol.65 (3), p.360-367
Main Authors: Tousen, Yuko, Wolber, Frances M., Chua, Wei-Hang, Tadaishi, Miki, Ishimi, Yoshiko, Kruger, Marlena C.
Format: Article
Language:English
Subjects:
Actinidia
Animals
Bone density
Bone Density - drug effects
Bone loss
bone mineral density
Cecum - drug effects
Cecum - microbiology
Diet
Dietary Supplements
Drug Synergism
Effects
Equol - biosynthesis
equol production
Female
Food science
Fruit
Fruits
Humans
intestinal microbiota
Isoflavones - pharmacology
Isoflavones - therapeutic use
Microbiology
Osteoporosis, Postmenopausal - metabolism
Osteoporosis, Postmenopausal - prevention & control
Ovariectomy
Phytoestrogens - pharmacology
Phytoestrogens - therapeutic use
Plant Preparations - pharmacology
Plant Preparations - therapeutic use
Rats
Rats, Sprague-Dawley
Rodents
soy isoflavone
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Summary:Abstract In this study, we investigated the synergistic effects of daidzein (Dz) and kiwifruit on bone and equol production in ovariectomised (OVX) rats. Female Sprague-Dawley rats were randomly assigned to one of five groups: sham operated, OVX control, OVX fed 0.1% Dz-supplemented diet (OVX + Dz), OVX fed 0.1% Dz and green kiwifruit (GRK)-supplemented diet (OVX + Dz + GRK) and OVX fed 0.1% Dz and gold kiwifruit (GOK)-supplemented diet (OVX + Dz + GOK). There were no significant differences in whole body and femur bone mineral density (BMD) among groups at week 8. BMD in the OVX group significantly decreased at week 8; however, BMD in the OVX + Dz + GRK was not significantly different from baseline in the end of the study. However, supplementation with kiwifruit did not affect urinary equol concentrations, urinary ratios of equol to Dz and the composition of caecal microbiota. These results suggest that the combination of Dz and GRK may slightly reduce bone loss caused by oestrogen deficiency but does not affect equol production.
ISSN:0963-7486
1465-3478
DOI:10.3109/09637486.2013.858238