Application of Electron Paramagnetic Resonance Spectroscopy for Validation of the Novel (AN+DN) Solvent Polarity Scale

Based on solvation studies of polymers, the sum (1:1) of the electron acceptor (AN) and electron donor (DN) values of solvents has been proposed as an alternative polarity scale. To test this, the electron paramagnetic resonance isotropic hyperfine splitting constant, a parameter known to be depende...

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Bibliographic Details
Published in:International journal of molecular sciences 2008-07, Vol.9 (7), p.1321-1332
Main Authors: Malavolta, Luciana, Poletti, Erick F., Silva, Elias H., Schreier, Shirley, Nakaie, Clovis R.
Format: Article
Language:English
Subjects:
Alzheimer's disease
Peptides
Regression analysis
Solvents
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Summary:Based on solvation studies of polymers, the sum (1:1) of the electron acceptor (AN) and electron donor (DN) values of solvents has been proposed as an alternative polarity scale. To test this, the electron paramagnetic resonance isotropic hyperfine splitting constant, a parameter known to be dependent on the polarity/proticity of the medium, was correlated with the (AN+DN) term using three paramagnetic probes. The linear regression coefficient calculated for 15 different solvents was approximately 0.9, quite similar to those of other well-known polarity parameters, attesting to the validity of the (AN+DN) term as a novel “two-parameter” solvent polarity scale.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms9071321