Synthesis, structure, and urease inhibitory activities of three binuclear copper(II) complexes with protocatechuic acid derivative

Three Cu(II) complexes, [Cu II 2 (L 1 ) 4 (L 2 ) 2 ] (1), [Cu II 2 (L 1 ) 4 (H 2 O) 2 ]·HL (2), and [Cu II 2 (L 1 ) 3 (L 3 ) 2 ]ClO 4 (3), with a ligand derived from protocatechuic acid (HL 1  = C 9 H 8 O 4 =2,3-dihydrobenzo[b][1,4]dioxine-6-carboxylic acid, L 2  = C 7 H 9 N=o-toluidine, L 3  = C 6...

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Bibliographic Details
Published in:Journal of coordination chemistry 2014-04, Vol.67 (7), p.1265-1278
Main Authors: Sheng, Gui-Hua, Zhou, Quan-Cheng, Sun, Juan, Cheng, Xiao-Shan, Qian, Shao-Song, Zhang, Chun-Yang, You, Zhong-Lu, Zhu, Hai-Liang
Format: Article
Language:English
Subjects:
Acids
Copper(II) complex
Crystal structure
Diffraction
Protocatechuic acid
Urease inhibitors
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Summary:Three Cu(II) complexes, [Cu II 2 (L 1 ) 4 (L 2 ) 2 ] (1), [Cu II 2 (L 1 ) 4 (H 2 O) 2 ]·HL (2), and [Cu II 2 (L 1 ) 3 (L 3 ) 2 ]ClO 4 (3), with a ligand derived from protocatechuic acid (HL 1  = C 9 H 8 O 4 =2,3-dihydrobenzo[b][1,4]dioxine-6-carboxylic acid, L 2  = C 7 H 9 N=o-toluidine, L 3  = C 6 H 16 N 2 =N,N-diethylethylenediamine) were synthesized and characterized by C, H, and N elemental analysis and single-crystal X-ray diffraction, which revealed that the three complexes have similar binuclear structures. Complexes 1 and 3 crystallized in triclinic space group P-1 and 2 in orthorhombic space group P2 1 2 1 2 1 . The urease inhibitory activities of the three complexes were tested. All three complexes showed strong inhibitory activity against jack bean urease with an IC 50 value of 6.8, 5.5, and 3.5 μM compared with the acetohydroxamic acid (IC 50  = 7.5 μM), which was a positive control.
ISSN:0095-8972
1029-0389
DOI:10.1080/00958972.2014.910597