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Insulin sensitivity index in type 1 diabetes and following human islet transplantation: comparison of the minimal model to euglycemic clamp measures
Insulin sensitivity is impaired in type 1 diabetes (T1D) and may be enhanced by islet transplantation, an effect best explained by improved metabolic control. While the minimal model index of insulin sensitivity, SI, has been used in studies of T1D, it has not before been evaluated against gold-stan...
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Published in: | American journal of physiology: endocrinology and metabolism 2014-05, Vol.306 (10), p.E217 |
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creator | Rickels, Michael R Kong, Stephanie M Fuller, Carissa Dalton-Bakes, Cornelia Ferguson, Jane F Reilly, Muredach P Teff, Karen L Naji, Ali |
description | Insulin sensitivity is impaired in type 1 diabetes (T1D) and may be enhanced by islet transplantation, an effect best explained by improved metabolic control. While the minimal model index of insulin sensitivity, SI, has been used in studies of T1D, it has not before been evaluated against gold-standard measures derived from the euglycemic clamp. We sought to determine how well minimal model SI derived from an insulin-modified frequently sampled intravenous glucose tolerance (FSIGT) test compared with total body and peripheral insulin sensitivity estimates derived from the hyperinsulinemic-euglycemic clamp in subjects with T1D and following islet transplantation. Twenty-one T1D subjects were evaluated, including a subgroup (n = 12) studied again after intrahepatic islet transplantation, with results compared with normal controls (n = 11 for the FSIGT). The transplant recipients received 9,648 ± 666 islet equivalents/kg with reduction in HbA1c from 7.1 ± 0.2 to 5.5 ± 0.1% (P < 0.01) and 10/12 were insulin independent. FSIGT-derived SI was reduced in T1D pre- compared with posttransplant and with normal [1.76 ± 0.45 vs. 4.21 ± 0.34 vs. 4.45 ± 0.81 ... 10-4(...U/ml)-1-min...; P < 0.01 for both]. Similarly, clamp-derived total body, and by the isotopic dilution method with [6,6-2H2]glucose, peripheral insulin sensitivity increased in T1D from pre- to posttransplant (P < 0.05 for both). The predictive power (r2) between volume-corrected S... and measures of total and peripheral insulin sensitivity was 0.66 and 0.70, respectively (P < 0.00001 for both). That the minimal model S... is highly correlated to the clamp-derived measures indicates that the FSIGT is an appropriate methodology for the determination of insulin sensitivity in T1D and following islet transplantation. (ProQuest: ... denotes formulae/symbols omitted.) |
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While the minimal model index of insulin sensitivity, SI, has been used in studies of T1D, it has not before been evaluated against gold-standard measures derived from the euglycemic clamp. We sought to determine how well minimal model SI derived from an insulin-modified frequently sampled intravenous glucose tolerance (FSIGT) test compared with total body and peripheral insulin sensitivity estimates derived from the hyperinsulinemic-euglycemic clamp in subjects with T1D and following islet transplantation. Twenty-one T1D subjects were evaluated, including a subgroup (n = 12) studied again after intrahepatic islet transplantation, with results compared with normal controls (n = 11 for the FSIGT). The transplant recipients received 9,648 ± 666 islet equivalents/kg with reduction in HbA1c from 7.1 ± 0.2 to 5.5 ± 0.1% (P < 0.01) and 10/12 were insulin independent. FSIGT-derived SI was reduced in T1D pre- compared with posttransplant and with normal [1.76 ± 0.45 vs. 4.21 ± 0.34 vs. 4.45 ± 0.81 ... 10-4(...U/ml)-1-min...; P < 0.01 for both]. Similarly, clamp-derived total body, and by the isotopic dilution method with [6,6-2H2]glucose, peripheral insulin sensitivity increased in T1D from pre- to posttransplant (P < 0.05 for both). The predictive power (r2) between volume-corrected S... and measures of total and peripheral insulin sensitivity was 0.66 and 0.70, respectively (P < 0.00001 for both). That the minimal model S... is highly correlated to the clamp-derived measures indicates that the FSIGT is an appropriate methodology for the determination of insulin sensitivity in T1D and following islet transplantation. (ProQuest: ... denotes formulae/symbols omitted.)</description><identifier>ISSN: 0193-1849</identifier><identifier>EISSN: 1522-1555</identifier><identifier>CODEN: AJPMD9</identifier><language>eng</language><publisher>Bethesda: American Physiological Society</publisher><subject>Comparative analysis ; Correlation analysis ; Diabetes ; Glucose ; Insulin ; Transplants & implants</subject><ispartof>American journal of physiology: endocrinology and metabolism, 2014-05, Vol.306 (10), p.E217</ispartof><rights>Copyright American Physiological Society May 15, 2014</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids></links><search><creatorcontrib>Rickels, Michael R</creatorcontrib><creatorcontrib>Kong, Stephanie M</creatorcontrib><creatorcontrib>Fuller, Carissa</creatorcontrib><creatorcontrib>Dalton-Bakes, Cornelia</creatorcontrib><creatorcontrib>Ferguson, Jane F</creatorcontrib><creatorcontrib>Reilly, Muredach P</creatorcontrib><creatorcontrib>Teff, Karen L</creatorcontrib><creatorcontrib>Naji, Ali</creatorcontrib><title>Insulin sensitivity index in type 1 diabetes and following human islet transplantation: comparison of the minimal model to euglycemic clamp measures</title><title>American journal of physiology: endocrinology and metabolism</title><description>Insulin sensitivity is impaired in type 1 diabetes (T1D) and may be enhanced by islet transplantation, an effect best explained by improved metabolic control. While the minimal model index of insulin sensitivity, SI, has been used in studies of T1D, it has not before been evaluated against gold-standard measures derived from the euglycemic clamp. We sought to determine how well minimal model SI derived from an insulin-modified frequently sampled intravenous glucose tolerance (FSIGT) test compared with total body and peripheral insulin sensitivity estimates derived from the hyperinsulinemic-euglycemic clamp in subjects with T1D and following islet transplantation. Twenty-one T1D subjects were evaluated, including a subgroup (n = 12) studied again after intrahepatic islet transplantation, with results compared with normal controls (n = 11 for the FSIGT). The transplant recipients received 9,648 ± 666 islet equivalents/kg with reduction in HbA1c from 7.1 ± 0.2 to 5.5 ± 0.1% (P < 0.01) and 10/12 were insulin independent. FSIGT-derived SI was reduced in T1D pre- compared with posttransplant and with normal [1.76 ± 0.45 vs. 4.21 ± 0.34 vs. 4.45 ± 0.81 ... 10-4(...U/ml)-1-min...; P < 0.01 for both]. Similarly, clamp-derived total body, and by the isotopic dilution method with [6,6-2H2]glucose, peripheral insulin sensitivity increased in T1D from pre- to posttransplant (P < 0.05 for both). The predictive power (r2) between volume-corrected S... and measures of total and peripheral insulin sensitivity was 0.66 and 0.70, respectively (P < 0.00001 for both). That the minimal model S... is highly correlated to the clamp-derived measures indicates that the FSIGT is an appropriate methodology for the determination of insulin sensitivity in T1D and following islet transplantation. (ProQuest: ... denotes formulae/symbols omitted.)</description><subject>Comparative analysis</subject><subject>Correlation analysis</subject><subject>Diabetes</subject><subject>Glucose</subject><subject>Insulin</subject><subject>Transplants & implants</subject><issn>0193-1849</issn><issn>1522-1555</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><recordid>eNqNjzFOw0AQRVeISBjIHUaitmQ7WSWmRSDo6aOJPU4m2p01nlnA9-DAuOAANP8V7zX_yhW1b5qy9t5fu6Kq201Z77ftjbtVvVRVtfPbpnA_b6I5sICSKBt_ss3A0tP3smDzSFBDz3gkIwWUHoYUQvpiOcE5RxRgDWRgE4qOAcXQOMkjdCmOOLEmgTSAnQkiC0cMEFNPASwB5VOYO4rcQRcwjhAJNU-k9241YFBa__HOPbw8vz-9luOUPjKpHS4pT7Kow_KxrXy797vN_6pfZhFarQ</recordid><startdate>20140515</startdate><enddate>20140515</enddate><creator>Rickels, Michael R</creator><creator>Kong, Stephanie M</creator><creator>Fuller, Carissa</creator><creator>Dalton-Bakes, Cornelia</creator><creator>Ferguson, Jane F</creator><creator>Reilly, Muredach P</creator><creator>Teff, Karen L</creator><creator>Naji, Ali</creator><general>American Physiological Society</general><scope>7QP</scope><scope>7TS</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>20140515</creationdate><title>Insulin sensitivity index in type 1 diabetes and following human islet transplantation: comparison of the minimal model to euglycemic clamp measures</title><author>Rickels, Michael R ; Kong, Stephanie M ; Fuller, Carissa ; Dalton-Bakes, Cornelia ; Ferguson, Jane F ; Reilly, Muredach P ; Teff, Karen L ; Naji, Ali</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-proquest_journals_15290598573</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Comparative analysis</topic><topic>Correlation analysis</topic><topic>Diabetes</topic><topic>Glucose</topic><topic>Insulin</topic><topic>Transplants & implants</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rickels, Michael R</creatorcontrib><creatorcontrib>Kong, Stephanie M</creatorcontrib><creatorcontrib>Fuller, Carissa</creatorcontrib><creatorcontrib>Dalton-Bakes, Cornelia</creatorcontrib><creatorcontrib>Ferguson, Jane F</creatorcontrib><creatorcontrib>Reilly, Muredach P</creatorcontrib><creatorcontrib>Teff, Karen L</creatorcontrib><creatorcontrib>Naji, Ali</creatorcontrib><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Physical Education Index</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>American journal of physiology: endocrinology and metabolism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rickels, Michael R</au><au>Kong, Stephanie M</au><au>Fuller, Carissa</au><au>Dalton-Bakes, Cornelia</au><au>Ferguson, Jane F</au><au>Reilly, Muredach P</au><au>Teff, Karen L</au><au>Naji, Ali</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Insulin sensitivity index in type 1 diabetes and following human islet transplantation: comparison of the minimal model to euglycemic clamp measures</atitle><jtitle>American journal of physiology: endocrinology and metabolism</jtitle><date>2014-05-15</date><risdate>2014</risdate><volume>306</volume><issue>10</issue><spage>E217</spage><pages>E217-</pages><issn>0193-1849</issn><eissn>1522-1555</eissn><coden>AJPMD9</coden><abstract>Insulin sensitivity is impaired in type 1 diabetes (T1D) and may be enhanced by islet transplantation, an effect best explained by improved metabolic control. While the minimal model index of insulin sensitivity, SI, has been used in studies of T1D, it has not before been evaluated against gold-standard measures derived from the euglycemic clamp. We sought to determine how well minimal model SI derived from an insulin-modified frequently sampled intravenous glucose tolerance (FSIGT) test compared with total body and peripheral insulin sensitivity estimates derived from the hyperinsulinemic-euglycemic clamp in subjects with T1D and following islet transplantation. Twenty-one T1D subjects were evaluated, including a subgroup (n = 12) studied again after intrahepatic islet transplantation, with results compared with normal controls (n = 11 for the FSIGT). The transplant recipients received 9,648 ± 666 islet equivalents/kg with reduction in HbA1c from 7.1 ± 0.2 to 5.5 ± 0.1% (P < 0.01) and 10/12 were insulin independent. FSIGT-derived SI was reduced in T1D pre- compared with posttransplant and with normal [1.76 ± 0.45 vs. 4.21 ± 0.34 vs. 4.45 ± 0.81 ... 10-4(...U/ml)-1-min...; P < 0.01 for both]. Similarly, clamp-derived total body, and by the isotopic dilution method with [6,6-2H2]glucose, peripheral insulin sensitivity increased in T1D from pre- to posttransplant (P < 0.05 for both). The predictive power (r2) between volume-corrected S... and measures of total and peripheral insulin sensitivity was 0.66 and 0.70, respectively (P < 0.00001 for both). That the minimal model S... is highly correlated to the clamp-derived measures indicates that the FSIGT is an appropriate methodology for the determination of insulin sensitivity in T1D and following islet transplantation. (ProQuest: ... denotes formulae/symbols omitted.)</abstract><cop>Bethesda</cop><pub>American Physiological Society</pub></addata></record> |
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subjects | Comparative analysis Correlation analysis Diabetes Glucose Insulin Transplants & implants |
title | Insulin sensitivity index in type 1 diabetes and following human islet transplantation: comparison of the minimal model to euglycemic clamp measures |
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