Longitudinal study of cognitive dysfunctions induced by adjuvant chemotherapy in colon cancer patients

• Published in: Supportive care in cancer 2014-07, Vol.22 (7), p.1815-1823
• Main Authors: Cruzado, Juan Antonio, López-Santiago, Sonia, Martínez-Marín, Virginia, José-Moreno, Gema, Custodio, Ana Belén, Feliu, Jaime
• Format: Article
• Language: English
• Subjects: Adjuvant treatment; Aged; Antineoplastic Combined Chemotherapy Protocols - administration & dosage; Antineoplastic Combined Chemotherapy Protocols - adverse effects; Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Cancer; Cancer patients; Care and treatment; Chemotherapy; Chemotherapy, Adjuvant - adverse effects; Cognition - drug effects; Cognition disorders; Cognition Disorders - chemically induced; Cognitive ability; Colon cancer; Colonic Neoplasms - drug therapy; Colonic Neoplasms - psychology; Colorectal cancer; Depression, Mental; Diagnostic tests; Female; Fluorouracil - administration & dosage; Fluorouracil - adverse effects; Hemoglobin; Humans; Leucovorin - administration & dosage; Leucovorin - adverse effects; Longitudinal Studies; Male; Medicine; Medicine & Public Health; Memory - drug effects; Middle Aged; Neuropsychology; Nursing; Nursing Research; Oncology; Oncology, Experimental; Organoplatinum Compounds - administration & dosage; Organoplatinum Compounds - adverse effects; Original Article; Pain Medicine; Rehabilitation Medicine
• ISSN: 0941-4355; 1433-7339
• DOI: 10.1007/s00520-014-2147-x

Background Chemotherapy can induce cognitive impairment in cancer patients. The main goal of this longitudinal study was to determine the incidence, characteristics, and duration of cognitive dysfunction in patients treated with adjuvant chemotherapy for colon cancer. Patients and methods We assessed cognitive function, quality of life, anxiety and depression, fatigue, and hemoglobin levels in colon cancer patients at three assessment points: pre-chemotherapy ( n  = 81), post-chemotherapy ( n  = 73), and after 6-month follow-up ( n  = 54). All patients were treated with oxaliplatin plus 5-fluorouracil/leucovorin (FOLFOX4) for 6 months. Results Thirty patients (37 %) had cognitive impairment in the pre-chemotherapy evaluation, mainly in processing speed and psychomotor executive function (Trail Making Test A and B). At the end of treatment, the main domain affected was the verbal memory, with an acute decline detected in 56 % of patients. Fifty-four percent of the patients improved their dysfunction after 6 months of follow-up, whereas 18 (33 %) of them showed worsening in at least one test. Cognitive impairment was most common in older patients and in those with less years of education. Quality of life, anxiety, depression, fatigue, and hemoglobin did not influence the results of the cognitive tests. Conclusions Adjuvant FOLFOX4 in patients with colon cancer can have a negative effect on verbal memory. This deterioration is usually mild and transient.