The correcting effects of dihydroquercetin in cerebral ischemia-reperfusion injury

The dynamics of changes in the mitochondrial respiratory function, changes in the parameters of carbohydrate metabolism and some parameters of oxidative stress in the brain tissue have been investigated under conditions of ischemia-reperfusion and administration of dihydroquercetin. Dihydroquercetin...

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Bibliographic Details
Published in:Biochemistry (Moscow). Supplement. Series B, Biomedical chemistry Biomedical chemistry, 2014-04, Vol.8 (2), p.150-154
Main Authors: Maksimovich, N. Ye, Dremza, I. K., Troyan, E. I., Maksimovich, Ya. N., Borodinskii, A. N.
Format: Article
Language:English
Subjects:
Bioorganic Chemistry
Brain
Carbohydrates
Chemistry
Chemistry and Materials Science
Ischemia
Medicinal Chemistry
Mitochondria
Oxidative stress
Respiration
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Summary:The dynamics of changes in the mitochondrial respiratory function, changes in the parameters of carbohydrate metabolism and some parameters of oxidative stress in the brain tissue have been investigated under conditions of ischemia-reperfusion and administration of dihydroquercetin. Dihydroquercetin (65 mg/kg) was administered per os 1 h before modeling of ischemia-reperfusion. Studies were carried 1 h after reperfusion. It was found that administration of dihydroquercetin caused a corrective effect to impairments of the respiratory function of mitochondria, indicators of carbohydrate metabolism and parameters of oxidative stress induced by ischemia-reperfusion.
ISSN:1990-7508
1990-7516
DOI:10.1134/S1990750814020073