Prostate cancer: performance characteristics of combined T^sub 2^W and DW-MRI scoring in the setting of template transperineal re-biopsy using MR-TRUS fusion

• Published in: European radiology 2014-07, Vol.24 (7), p.1497
• Main Authors: Lawrence, Edward M, Tang, Sarah Y, W, Barrett, Tristan, Koo, Brendan, Goldman, Debra A, Warren, Anne Y, Axell, Richard G, Doble, Andrew, Gallagher, Ferdia A, Gnanapragasam, Vincent J, Kastner, Christof, Sala, Evis
• Format: Article
• Language: English
• Subjects: Biopsy; Clinical significance; Hospitals; Magnetic resonance imaging; Patients; Performance evaluation; Prostate cancer; Ultrasonic imaging
• ISSN: 0938-7994; 1432-1084
• DOI: 10.1007/s00330-014-3159-0

To measure the performance characteristics of combined T^sub 2^-weighted (T^sub 2^W) and diffusion-weighted (DW) magnetic resonance imaging (MRI) suspicion scoring prior to MR-transrectal ultrasound (TRUS) fusion template transperineal (TTP) re-biopsy. Thirty-nine patients referred for prostate re-biopsy, with prior MRI examinations, were retrospectively included. The MR images, including T^sub 2^W and DW-MRI, had been independently evaluated prospectively by two radiologists using a structured scoring system. An MR-TRUS fusion TTP re-biopsy was used for MR target and non-targeted biopsy cores. Targeting performance and correlation with disease status were evaluated on a per-patient and per-region basis. The cancer yield was 41 % (16/39 patients). MR targeting accurately detected the disease in 12/16 (75 %) cancerous patients and missed the disease in 4/16 (25 %) patients, all with Gleason 3+3 disease. There was a significant relationship (P