Effect of ganglioside GM1 on mitochondrial respiration and viability of PC12 cells under oxidative stress

Gangliosides, typical components of nerve cell membranes, are glycosphingolipids containing sialic acids. The major brain gangliosides (GM1, GD1a, GD1b, and GT1b) upon their administration to animals with ischemic, traumatic, and toxic brain lesions are known to prevent its nerve cells from death. T...

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Bibliographic Details
Published in:Journal of evolutionary biochemistry and physiology 2014-03, Vol.50 (2), p.174-176
Main Authors: Brailovskaya, I. V., Sokolova, T. V., Kobylyanskii, A. G., Avrova, N. F.
Format: Article
Language:English
Subjects:
Animal Physiology
Biochemistry
Biomedical and Life Sciences
Cells
Evolutionary Biology
Life Sciences
Mitochondria
Neurons
Oxidative stress
Short Communications
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Summary:Gangliosides, typical components of nerve cell membranes, are glycosphingolipids containing sialic acids. The major brain gangliosides (GM1, GD1a, GD1b, and GT1b) upon their administration to animals with ischemic, traumatic, and toxic brain lesions are known to prevent its nerve cells from death. They increase viability of neurons and of cells of neuronal lines under action on them of glutamate and other toxins. Most often used in experiments of such type is the most stable of these gangliosidesGM.
ISSN:0022-0930
1608-3202
DOI:10.1134/S0022093014020100