The Changing Geometry of a Fitness Landscape Along an Adaptive Walk: e1003520

It has recently been noted that the relative prevalence of the various kinds of epistasis varies along an adaptive walk. This has been explained as a result of mean regression in NK model fitness landscapes. Here we show that this phenomenon occurs quite generally in fitness landscapes. We propose a...

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Bibliographic Details
Published in:PLoS computational biology 2014-05, Vol.10 (5)
Main Authors: Greene, Devin, Crona, Kristina
Format: Article
Language:English
Subjects:
Confidence intervals
Genotype & phenotype
Geometry
Graphs
Mutation
Programming languages
Online Access:Get full text
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Summary:It has recently been noted that the relative prevalence of the various kinds of epistasis varies along an adaptive walk. This has been explained as a result of mean regression in NK model fitness landscapes. Here we show that this phenomenon occurs quite generally in fitness landscapes. We propose a simple and general explanation for this phenomenon, confirming the role of mean regression. We provide support for this explanation with simulations, and discuss the empirical relevance of our findings.
ISSN:1553-734X
1553-7358
DOI:10.1371/journal.pcbi.1003520