VPS35 Parkinson’s disease phenotype resembles the sporadic disease

Recently a new autosomal dominant Parkinson’s disease mutation (p.Asp620Asn) in the VPS35 gene was discovered. The clinical features of 14 PD patients with this mutation from three Austrian families were evaluated. Age at disease-onset appears lower and depression was more common in Austrian patient...

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Bibliographic Details
Published in:Journal of Neural Transmission 2014-07, Vol.121 (7), p.755-759
Main Authors: Struhal, Walter, Presslauer, Stefan, Spielberger, Sabine, Zimprich, Alexander, Auff, Eduard, Bruecke, Thomas, Poewe, Werner, Ransmayr, Gerhard
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Databases, Factual - statistics & numerical data
Female
Genetic Predisposition to Disease - genetics
Humans
Male
Medicine
Medicine & Public Health
Middle Aged
Neurology
Neurology and Preclinical Neurological Studies - Short communication
Neurosciences
Parkinson Disease - genetics
Parkinson's disease
Phenotype
Psychiatry
Vesicular Transport Proteins - genetics
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Summary:Recently a new autosomal dominant Parkinson’s disease mutation (p.Asp620Asn) in the VPS35 gene was discovered. The clinical features of 14 PD patients with this mutation from three Austrian families were evaluated. Age at disease-onset appears lower and depression was more common in Austrian patients compared to sporadic PD patients. However, we were unable to identify a specific clinical maker of VPS35 patients, who otherwise resemble sporadic PD patients.
ISSN:0300-9564
1435-1463
DOI:10.1007/s00702-014-1179-1