The stimulating influence of thienopyrimidine compounds on the adenylyl cyclase signaling systems in the rat testes

The purpose of this study was to investigate the effect of newly synthesized analogues of Org43553, 5 amino N (tert butyl) 4 (3 (isonicotinamido)phe nyl) 2 (methylthio)thieno[2,3 d]pyrimidine 6 car boxamide (compound 1) and 5 amine N (tert butyl) 2 (methylthio) 4 (3 (thiophen 3 carboxamido)phe nyl)t...

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Published in:Doklady. Biochemistry and biophysics 2014-05, Vol.456 (1), p.104-107
Main Authors: Shpakov, A. O., Dar’in, D. V., Derkach, K. V., Lobanov, P. S.
Format: Article
Language:English
Subjects:
Adenylyl Cyclases - metabolism
Animals
Biochemistry
Biological and Medical Physics
Biomedical and Life Sciences
Biophysics
Biophysics and Molecular Biology
Biosynthesis
Cell Membrane - drug effects
Cell Membrane - enzymology
Chorionic Gonadotropin - metabolism
Dose-Response Relationship, Drug
Guanosine Triphosphate - metabolism
Humans
Life Sciences
Male
Pyrimidines - chemical synthesis
Pyrimidines - pharmacology
Rabbits
Rats, Wistar
Receptors, LH - agonists
Receptors, LH - metabolism
Reproductive system
Rodents
Signal Transduction - drug effects
Testis - drug effects
Testis - enzymology
Testosterone
Thiophenes - chemical synthesis
Thiophenes - pharmacology
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Summary:The purpose of this study was to investigate the effect of newly synthesized analogues of Org43553, 5 amino N (tert butyl) 4 (3 (isonicotinamido)phe nyl) 2 (methylthio)thieno[2,3 d]pyrimidine 6 car boxamide (compound 1) and 5 amine N (tert butyl) 2 (methylthio) 4 (3 (thiophen 3 carboxamido)phe nyl)thieno[2,3 d]pyrimidine 6 carboxamide (com pound 2) (Fig. 1) on the functional activity of LH sensitive adenylyl cyclase signaling system (ACSS) in rat testes. ACSS was selected as a study object because it is the main target of action of LH and thienopyrimidines[7] and mediates the most important biological effects of LH, including the regulation of synthesis and secretion of testosterone by Leydig cells.
ISSN:1607-6729
1608-3091
DOI:10.1134/S1607672914030065