Intravoxel incoherent motion diffusion-weighted MR imaging in differentiation of lung cancer from obstructive lung consolidation: comparison and correlation with pharmacokinetic analysis from dynamic contrast-enhanced MR imaging

Objectives To test whether parameters derived from intravoxel incoherent motion (IVIM) can be used to distinguish lung cancer from obstructive pulmonary consolidation by comparing them with dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI)-derived parameters and to evaluate the correlat...

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Bibliographic Details
Published in:European radiology 2014-08, Vol.24 (8), p.1914-1922
Main Authors: Wang, Li-li, Lin, Jiang, Liu, Kai, Chen, Cai-zhong, Liu, Hui, Lv, Peng, Fu, Cai-xia, Zeng, Meng-su
Format: Article
Language:English
Subjects:
Adult
Aged
Contrast Media - pharmacokinetics
Diagnosis, Differential
Diagnostic Radiology
Diffusion Magnetic Resonance Imaging - methods
Female
Humans
Image Interpretation, Computer-Assisted
Imaging
Internal Medicine
Interventional Radiology
Lung cancer
Lung Neoplasms - diagnosis
Lung Neoplasms - metabolism
Magnetic Resonance
Magnetic resonance imaging
Male
Medicine
Medicine & Public Health
Middle Aged
Motion
Neuroradiology
Pharmacokinetics
Positron-Emission Tomography - methods
Prospective Studies
Pulmonary Disease, Chronic Obstructive - diagnosis
Pulmonary Disease, Chronic Obstructive - metabolism
Radiology
Reproducibility of Results
Tomography
Tumors
Ultrasound
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Summary:Objectives To test whether parameters derived from intravoxel incoherent motion (IVIM) can be used to distinguish lung cancer from obstructive pulmonary consolidation by comparing them with dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI)-derived parameters and to evaluate the correlation between these quantitative parameters. Methods A total of 31 lung cancer patients, confirmed by pathology and obstructive consolidations confirmed by positron emission tomography/computed tomography (PET-CT), were recruited. All of them were assessed with structural MRI and IVIM and 17 of them underwent additional DCE-MRI examinations. Parameters derived from IVIM and DCE-MRI in the tumour and consolidation were analysed, and the optimal cut-off values in differential diagnosis were obtained. Results ADC total , D and f values were lower ( P  
ISSN:0938-7994
1432-1084
DOI:10.1007/s00330-014-3176-z