Effect of ^sup 131^I Gelatin Microspheres on Hepatocellular Carcinoma in Nude Mice and its Distribution after Intratumoral Injection

In this study, we investigated the effect of ^sup 131^I gelatin microspheres (^sup 131^I-GMSs) on human hepatocellular carcinoma cells (HepG2) in nude mice (Balb/c) and the biodistribution of ^sup 131^I-GMSs after intratumoral injection. The treatment group and control group animals received intratu...

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Bibliographic Details
Published in:Radiation research 2014-04, Vol.181 (4), p.416
Main Authors: Chi, Jun-Lin, Li, Chuan-Chao, Xia, Chuan-Qin, Li, Lin, Ma, Yu, Li, Jian-Hong, Chen, Zhuo, Chen, Xiao-Li
Format: Article
Language:English
Subjects:
Computed tomography
Injection
Thyroid
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Summary:In this study, we investigated the effect of ^sup 131^I gelatin microspheres (^sup 131^I-GMSs) on human hepatocellular carcinoma cells (HepG2) in nude mice (Balb/c) and the biodistribution of ^sup 131^I-GMSs after intratumoral injection. The treatment group and control group animals received intratumoral injections of 1 mCi ^sup 131^I-GMSs and GMSs unlabeled ^sup 131^I, respectively. The size of the implanted tumor was measured once a week for 8 weeks, and the survival time was calculated from the day of injection to 64 days post-injection. Another 35 animals received intratumoral injections of 0.2 mCi ^sup 131^IGMSs and were subject to single-photon emission computed tomography on days 1, 8, 16, 24 and 32 postinjection. Samples of various organs were collected and used, to calculate tissue concentrations on days 1, 4, 8, 16 and 24. Free thyroxine (FT4) in fetal bovine serum was tested to evaluate thyroid function. The tumors were collected for histological examination. The concentration of FT4 was stable during the observation period.
ISSN:0033-7587
1938-5404