Differential Patterns of Serum Brain-Derived Neurotrophic Factor Levels in Alcoholic Patients With and Without Delirium Tremens During Acute Withdrawal

Background:  Brain‐derived neurotrophic factor (BDNF) is associated with alcohol addiction and withdrawal‐related neurotoxicity. Delirium tremens (DT) is the most serious complication of alcohol withdrawal syndrome (AWS). In this study, we explored the differences in serum BDNF levels, measured at b...

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Published in:Alcoholism, clinical and experimental research clinical and experimental research, 2011-01, Vol.35 (1), p.126-131
Main Authors: Huang, Ming-Chyi, Chen, Chun-Hsin, Liu, Hsing-Cheng, Chen, Chiao-Chicy, Ho, Chia-Chen, Leu, Sy-Jye
Format: Article
Language:English
Subjects:
Addictive behaviors
Adult
Adult and adolescent clinical studies
Alcohol Dependence
Alcohol Withdrawal
Alcohol Withdrawal Delirium - blood
Alcoholism
Alcoholism - blood
Alcoholism and acute alcohol poisoning
Anticonvulsants - administration & dosage
Biological and medical sciences
Brain-Derived Neurotrophic Factor (BDNF)
Brain-Derived Neurotrophic Factor - blood
Central Nervous System Depressants - adverse effects
Delirium Tremens
Ethanol - adverse effects
Female
Humans
Liver Function Tests
Lorazepam - administration & dosage
Male
Medical sciences
Middle Aged
Psychiatric Status Rating Scales
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Substance Withdrawal Syndrome - blood
Time Factors
Toxicology
Young Adult
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Summary:Background:  Brain‐derived neurotrophic factor (BDNF) is associated with alcohol addiction and withdrawal‐related neurotoxicity. Delirium tremens (DT) is the most serious complication of alcohol withdrawal syndrome (AWS). In this study, we explored the differences in serum BDNF levels, measured at baseline and 1 week after alcohol withdrawal among alcoholic patients with and without DT. Methods:  Sixty‐five inpatients, fulfilling the DSM‐IV criteria of alcohol dependence and admitted for alcohol detoxification, as well as 39 healthy control subjects were enrolled. The alcoholic patients were divided by the appearance of DTs into the DT group (n = 25) and non‐DT group (n = 40). We collected blood samples of the patient groups on the first and seventh days of alcohol withdrawal and measured serum BDNF levels by sandwich enzyme‐linked immunosorbent assay. Results:  Serum BDNF levels differed significantly among the three groups: (i) control group 14.8 ± 4.7 ng/ml; (ii) non‐DT group 12.3 ± 3.3 ng/ml; (iii) DT group 6.2 ± 2.6 ng/ml (p 
ISSN:0145-6008
1530-0277
DOI:10.1111/j.1530-0277.2010.01329.x