Meibomian gland loss due to trabeculectomy

Purpose To evaluate meibomian gland loss after trabeculectomy with mitomycin C (MMC). Methods This cross-sectional observational case study involved 55 eyes in 39 patients who had undergone trabeculectomy with MMC administered to the upper area of the eye. We used a mobile pen-shaped noncontact meib...

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Bibliographic Details
Published in:Japanese journal of ophthalmology 2014-07, Vol.58 (4), p.334-341
Main Authors: Sagara, Hideto, Sekiryu, Tetsuju, Noji, Hiroki, Ogasawara, Masashi, Sugano, Yukinori, Horikiri, Hiroko
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Alkylating Agents - administration & dosage
Blister - diagnosis
Blister - etiology
Clinical Investigation
Conjunctiva - drug effects
Conjunctiva - surgery
Cross-Sectional Studies
Eyelid Diseases - diagnosis
Eyelid Diseases - etiology
Female
Glaucoma - surgery
Humans
Male
Medicine
Medicine & Public Health
Meibomian Glands - pathology
Middle Aged
Mitomycin - administration & dosage
Ophthalmology
Surgical Flaps
Tears - chemistry
Trabeculectomy - adverse effects
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Summary:Purpose To evaluate meibomian gland loss after trabeculectomy with mitomycin C (MMC). Methods This cross-sectional observational case study involved 55 eyes in 39 patients who had undergone trabeculectomy with MMC administered to the upper area of the eye. We used a mobile pen-shaped noncontact meibography system to access the morphology and determine loss of the meibomian glands. Meibomian gland loss was scored (meiboscore) from grade 0 (no loss of the meibomian glands) through grade 3 (loss of more than two-thirds of the total area) in the bleb-contacting and bleb-noncontacting upper eyelid areas in the primary position and in the lower eyelid. The tear film breakup time (BUT) was also measured. Results The median duration from trabeculectomy to examination was 7.4 years (interquartile range 3.1–14.2). The meiboscores of the bleb-contacting upper eyelid areas were significantly higher than those for the bleb-noncontacting upper eyelid areas ( P  
ISSN:0021-5155
1613-2246
DOI:10.1007/s10384-014-0324-6