Single Nucleotide Variances Can Account for Loss of microRNA Function

[...]they identified a unique single nucleotide polymorphism (SNP) (rs2266788) located in the 3' UTR region of the APOA5 transcript, which changes a single nucleotide from a T to a C. This SNP had a robust correlation with elevated plasma triglyceride levels and vascular lesions.

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Bibliographic Details
Published in:Journal of the American College of Cardiology 2014-07, Vol.64 (3), p.278-280
Main Authors: Li, Ren-Ke, MD, PhD, Guo, Jian, MD, PhD
Format: Article
Language:English
Subjects:
Apolipoproteins
Atherosclerosis
Cardiology
Cardiovascular
Cholesterol
DNA methylation
Epigenetics
Gene expression
Genomes
Internal Medicine
Lipoproteins
MicroRNAs
Plasma
Proteins
Rodents
Studies
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Description
Summary:[...]they identified a unique single nucleotide polymorphism (SNP) (rs2266788) located in the 3' UTR region of the APOA5 transcript, which changes a single nucleotide from a T to a C. This SNP had a robust correlation with elevated plasma triglyceride levels and vascular lesions.
ISSN:0735-1097
1558-3597
DOI:10.1016/j.jacc.2014.04.045