Working across the veterinary and human health sectors

• Published in: Journal of antimicrobial chemotherapy 2012-07, Vol.67 Suppl 1 (suppl 1), p.i37-i49
• Main Authors: Garcia-Alvarez, Laura, Dawson, Susan, Cookson, Barry, Hawkey, Peter
• Format: Article
• Language: English
• Subjects: Animals; Antibiotics; Disease Vectors; Drug resistance; Drug Resistance, Multiple, Bacterial; Food Microbiology; Gram-Negative Bacteria - pathogenicity; Gram-Negative Bacterial Infections - microbiology; Gram-Negative Bacterial Infections - prevention & control; Gram-Negative Bacterial Infections - transmission; Health Personnel; Humans; Interdisciplinary Communication; Livestock - microbiology; Methicillin-Resistant Staphylococcus aureus - pathogenicity; Multidrug resistant organisms; Occupational Exposure - prevention & control; Occupational safety; Staphylococcal Infections - microbiology; Staphylococcal Infections - prevention & control; Staphylococcal Infections - transmission; Staphylococcus infections; United Kingdom; Veterinary medicine
• ISSN: 0305-7453; 1460-2091
• DOI: 10.1093/jac/dks206

Antibiotics are widely used in human and veterinary medicine for the prevention and treatment of infectious diseases. This practice has led to the emergence of antimicrobial-resistant bacteria in both humans and animals. The potential role that animals, particularly livestock, might play as potential reservoirs of antibiotic resistance genes has been recognized, and it is currently a cause of public health concern. The impact of animal and human antibiotic usage on the emergence and persistence of resistant bacteria and the precise transfer pathways for resistance genes between humans and animals are not currently fully understood. As part of the remit of the UK Advisory Committee on Antimicrobial Resistance and Healthcare-Associated Infection (ARHAI), two main areas were addressed, namely methicillin-resistant Staphylococcus aureus (MRSA) and multidrug-resistant Gram-negative bacteria, where both the human and veterinary health sectors share interests. We review the current knowledge of MRSA and resistant Gram-negative bacteria, and provide guidance on occupational risks for veterinary healthcare workers relating to animals infected or colonized with MRSA. Findings and recommendations for further work across disciplines and future research in multidrug-resistant Gram-negative bacteria are also presented. Working collaboratively across disciplines is essential in order to better understand and challenge an important human and animal health problem: antimicrobial resistance.