Interleukin-12 induces a Th1-like response toBurkholderia malleiand limited protection in BALB/c mice

We evaluated the effect of interleukin (IL)-12 on the immune response toBurkholderia malleiin BALB/c mice. Mice were vaccinated with non-viableB. malleicells with or without IL-12. There was a seven- to nine-fold increase in IgG2a levels, and a significant increase in the proliferative response and...

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Bibliographic Details
Published in:Vaccine 2006-02, Vol.24 (9), p.1413
Main Authors: Amemiya, Kei, Meyers, Jennifer L, Trevino, Sylvia R, Chanh, Tran C, Norris, Sarah L, Waag, David M
Format: Article
Language:English
Subjects:
Cell culture
Cytokines
Glycerol
Immune response
Immune system
Infections
Laboratory animals
Medical research
Studies
Vaccines
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Summary:We evaluated the effect of interleukin (IL)-12 on the immune response toBurkholderia malleiin BALB/c mice. Mice were vaccinated with non-viableB. malleicells with or without IL-12. There was a seven- to nine-fold increase in IgG2a levels, and a significant increase in the proliferative response and interferon (IFN)-γ production by splenocytes from mice that receivedB. malleiand IL-12. We saw an increase in survivors in the groups of mice that receivedB. malleiand IL-12 when challenged, compared to mice that received onlyB. malleior IL-12. The results suggest that IL-12 can enhance the Th1-like immune response toB. malleiand mediate limited protection from a lethal challenge.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2005.09.021