Targeting subcapsular antigens for prevention ofKlebsiella pneumoniaeinfections

Vaccination strategies againstKlebsiella pneumoniaehave largely focussed on the polysaccharide capsule. However, the large number and high prevalence of individual capsular serotypes limits the widespread applicability of capsule-based vaccines. This study establishes that immunization with purified...

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Bibliographic Details
Published in:Vaccine 2008-10, Vol.26 (44), p.5649
Main Authors: Clements, Abigail, Jenney, Adam W, Farn, Jacinta L, Brown, Lorena E, Deliyannis, Georgia, Hartland, Elizabeth L, Pearse, Martin J, Maloney, Margaret B, Wesselingh, Steven L, Wijburg, Odilia L, Strugnell, Richard A
Format: Article
Language:English
Subjects:
Animals
Bacteria
Bacteriology
Experiments
Immunization
Infections
Lipids
Microscopy
Phenols
Prophylaxis
Proteins
Statistical analysis
Vaccines
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Summary:Vaccination strategies againstKlebsiella pneumoniaehave largely focussed on the polysaccharide capsule. However, the large number and high prevalence of individual capsular serotypes limits the widespread applicability of capsule-based vaccines. This study establishes that immunization with purified LPS can protect mice against lethal challenge withK. pneumoniae, and that subcapsular antibodies directed against purified LPS can be used to treat and/or prevent experimentalK. pneumoniaeinfection in mice. This approach offers potential for prophylaxis and/or therapy against drug-resistant strains ofK. pneumoniae.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2008.07.100