In Vitro Characterization of Novel Protegrin-1 Analogues Against Neoplastic Cells

Even with the great advances in cancer therapies, cancer remains the major cause of death worldwide. The use of high doses of anti-cancer chemotherapeutic drugs eventually causes the inevitable damage in non-neoplastic cells. New, selective, and more effective drugs are therefore urgently required t...

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Bibliographic Details
Published in:International journal of peptide research and therapeutics 2014-09, Vol.20 (3), p.259-267
Main Authors: Rothan, Hussin A., Mohamed, Zulqarnain, Sasikumar, Pottayil G., Reddy, Ketha Amarnadh, Rahman, Noorsaadah Abd, Yusof, Rohana
Format: Article
Language:English
Subjects:
Animal Anatomy
Biochemistry
Biomedical and Life Sciences
Breast cancer
Cellular biology
Chemotherapy
Histology
Life Sciences
Molecular Medicine
Morphology
Peptides
Pharmaceutical sciences
Pharmaceutical Sciences/Technology
Pharmacology/Toxicology
Polymer Sciences
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Summary:Even with the great advances in cancer therapies, cancer remains the major cause of death worldwide. The use of high doses of anti-cancer chemotherapeutic drugs eventually causes the inevitable damage in non-neoplastic cells. New, selective, and more effective drugs are therefore urgently required to fight cancer. In this study, the anticancer activity of new peptide analogues (P1 and P2) derived from natural peptide, protegrin-1 (PG-1) were evaluated against human breast carcinoma cell lines (MCF-7) and human non-neoplastic mammary epithelial cell lines (MCF-10A), human hepatocellular carcinoma cells (HepG2) and Vero cells. The CC 50 values of cancer cells were significantly lower ( P  
ISSN:1573-3149
1573-3904
DOI:10.1007/s10989-013-9388-2