Peripartum Cardiomyopathy

• Published in: Journal of the American College of Cardiology 2014-07, Vol.63 (25), p.2831-2839
• Main Authors: Pillarisetti, Jayasree, MD, MSc, Kondur, Ashok, MD, Alani, Anas, MD, Reddy, Madhu, MD, Reddy, Madhuri, MD, Vacek, James, MD, MSc, Weiner, Carl P., MD, Ellerbeck, Edward, MD, MPH, Schreiber, Theodore, MD, Lakkireddy, Dhanunjaya, MD
• Format: Article
• Language: English
• Subjects: African Americans; Age; Cardiology; Cardiomyopathy; Cardiovascular; Confidence intervals; Diabetes; Disease; Drug therapy; Enzymes; Family medical history; Heart; Heart attacks; Hypertension; implantable cardioverter-defibrillator; Internal Medicine; Medical records; Mortality; Multivariate analysis; peripartum; Preeclampsia; Statistical analysis; Studies; Ultrasonic imaging
• ISSN: 0735-1097; 1558-3597
• DOI: 10.1016/j.jacc.2014.04.014

Objectives The purpose of this study was to identify the predictors of left ventricular (LV) recovery in patients with peripartum cardiomyopathy (PPCM) and to record rates of implantable cardioverter-defibrillator (ICD) use. Background PPCM is a rare, life-threatening disease. The use of ICDs has not been clearly understood in this patient group. Identification of the predictors of persistent LV dysfunction can help select patients at risk for sudden cardiac death. Methods A retrospective study was conducted at 2 academic centers between January 1, 1999, and December 31, 2012. Clinical and demographic variables and delivery records of patients with a diagnosis of PPCM ( International Classification of Diseases, 9th Revision code 674.5) were reviewed. Improvement in LV function was noted from echocardiography reports. Results The total sample comprised 100 patients, of whom 55% were African Americans, 39% were Caucasians, and 6% were Hispanic, with a mean age of 30 ± 6 years. Mean left ventricular ejection fraction (LVEF) at diagnosis was 28 ± 9%. Forty-two percent of patients showed improvement in LVEF over a mean duration of 33 ± 21 months. Postpartum diagnosis (hazard ratio: 3.0; p = 0.01) and Caucasian/Hispanic race (hazard ratio: 2.2; p = 0.01) were predictors of improvement in LVEF. Only 7 of the 58 patients (12%) who did not have improvement in their LVEF had an ICD implanted. There were 11 deaths, with a trend toward higher mortality in those who did not display improved LV function (15% vs. 5%; p = 0.1). Conclusions More than one-third of women with PPCM improve LV function with delayed recovery noted in the majority of these patients. Caucasians and those diagnosed in the postpartum period appear to be the most likely to recover. The rate of ICD implantation for primary prevention of sudden cardiac death in this patient group is low.