IMPACT OF HIGH-FAT, LOW-CARBOHYDRATE DIET ON INSULIN SENSITIVITY AND TCA CYCLE SUBSTRATE ENTRY DURING ISCHEMIA-REPERFUSION

Isolated hearts were subjected to 30 min low flow ischemia (0.3 ml/min) followed by 60 min reperfusion, using a physiologic substrate mixture and carbon-13 labeled substrates, and TCA cycle entry determined by C-13 NMR spectroscopy.

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Bibliographic Details
Published in:Journal of the American College of Cardiology 2012-03, Vol.59 (13), p.E438-E438
Main Authors: Lloyd, Steven G, Wang, Peipei, Tate, Joshua M, Douglas, Samuel L
Format: Article
Language:English
Subjects:
Cardiology
Cardiovascular
Diet
Insulin
Internal Medicine
Ischemia
Phosphorylation
Rodents
Online Access:Get full text
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Description
Summary:Isolated hearts were subjected to 30 min low flow ischemia (0.3 ml/min) followed by 60 min reperfusion, using a physiologic substrate mixture and carbon-13 labeled substrates, and TCA cycle entry determined by C-13 NMR spectroscopy.
ISSN:0735-1097
1558-3597
DOI:10.1016/S0735-1097(12)60439-2