THE ROLE OF ANTI-RO/SSA ANTIBODY LEVEL IN CONGENITAL HEART BLOCK AND POSSIBLE BENEFIT OF MATERNAL THERAPY WITH ANTI-INFLAMMATORY AGENTS

There was no significant difference in semi-quantitative maternal anti-Ro antibody level in pregnancies complicated by fetal heart block versus those that maintained normal conduction. 94% of the infants maintained normal conduction when the mother was treated with hydroxychloroquine or daily predni...

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Bibliographic Details
Published in:Journal of the American College of Cardiology 2012-03, Vol.59 (13), p.E765-E765
Main Authors: Tunks, Robert, Clowse, Megan, Brancazio, Leo, Barker, Piers
Format: Article
Language:English
Subjects:
Cardiology
Cardiovascular
Fetuses
Heart
Internal Medicine
Pregnancy
Online Access:Get full text
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Summary:There was no significant difference in semi-quantitative maternal anti-Ro antibody level in pregnancies complicated by fetal heart block versus those that maintained normal conduction. 94% of the infants maintained normal conduction when the mother was treated with hydroxychloroquine or daily prednisone therapy throughout the pregnancy, compared to 56% in the untreated group (odds ratio: 0.09; 95% CI: 0.002, 0.84; p-value: 0.02).
ISSN:0735-1097
1558-3597
DOI:10.1016/S0735-1097(12)60766-9