WNT16B from Ovarian Fibroblasts Induces Differentiation of Regulatory T Cells through [beta]-Catenin Signal in Dendritic Cells

Treatment for cancer can induce a series of secreted factors into the tumor microenvironment, which can affect cancer progression. Wingless-type MMTV (mouse mammary tumor virus) integration site 16B (WNT16B) is a new member of the WNT family and has been reported to play growth-related roles in prev...

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Bibliographic Details
Published in:International journal of molecular sciences 2014-07, Vol.15 (7), p.12928
Main Authors: Shen, Cong-Cong, Kang, Yu-Huan, Zhao, Ming, He, Yi, Cui, Dan-Dan, Fu, Yu-Yin, Yang, Ling-Lin, Gou, Lan-Tu
Format: Article
Language:English
Subjects:
Lymphocytes
Ovarian cancer
Protein expression
Signal transduction
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Summary:Treatment for cancer can induce a series of secreted factors into the tumor microenvironment, which can affect cancer progression. Wingless-type MMTV (mouse mammary tumor virus) integration site 16B (WNT16B) is a new member of the WNT family and has been reported to play growth-related roles in previous studies. In this study, we found WNT16B could be expressed and secreted into the microenvironment by human ovarian fibroblasts after DNA damage-associated treatment, including chemotherapy drugs and radiation. We also demonstrated that fibroblast-derived WNT16B could result in accumulation of β-catenin in dendritic cells and secretion of interleukin-10 (IL-10) and transforming growth factor beta (TGF-β), which contributed to the differentiation of regulatory T cells in a co-culture environment. These results shed light on the roles of WNT16B in immune regulation, especially in regard to cancer treatment.
ISSN:1661-6596
1422-0067
DOI:10.3390/ijms150712928