Early and late postoperative inflammatory and collagen deposition responses in three different meshes: an experimental study in rats

• Published in: Hernia : the journal of hernias and abdominal wall surgery 2014-08, Vol.18 (4), p.563-570
• Main Authors: Pereira-lucena, C. G., Artigiani Neto, R., de Rezende, D. T., Lopes-Filho, G. de J., Matos, D., Linhares, M. M.
• Format: Article
• Language: English
• Subjects: Abdominal Surgery; Animals; Collagen - metabolism; Disease Models, Animal; Herniorrhaphy - adverse effects; Inflammation - etiology; Inflammation - metabolism; Male; Medicine; Medicine & Public Health; Original Article; Polyglactin 910 - adverse effects; Polypropylenes - adverse effects; Rats; Rats, Wistar; Surgical Mesh - adverse effects; Titanium - adverse effects; Vascular Endothelial Growth Factor A - metabolism; Wound Healing
• ISSN: 1265-4906; 1248-9204
• DOI: 10.1007/s10029-013-1206-4

Purpose Although meshes reduce abdominal hernia recurrence, they increase the risk of inflammatory complications. This study aimed to compare the early and late postoperative inflammation and collagen deposition responses induced by three meshes. Methods Rats were allocated into three groups. In group I, a polypropylene (PP) mesh was implanted in the abdominal wall. In groups II and III, PP + polyglactin (PP + PG) and PP + titanium (PP + TI) meshes were employed, respectively. On the seventh (7th) postoperative day, collagen deposition and inflammation were evaluated, and immunohistochemistry was performed on abdominal wall biopsies. These data were compared with those obtained on the fortieth (40th) postoperative day in a previous study. Results The early inflammatory responses were the same in all groups. With time, it decreased in group I ( p  = 0.047) and increased in group II ( p  = 0.003). Group I exhibited early elevated VEGF ( p