Persistence of immunity and seroprotection 4 years after a primary vaccination schedule with aHansenula polymorpharecombinant hepatitis B vaccine

To evaluate the persistence of the immune response in a population of healthy volunteers that had been vaccinated with a newHansenula polymorpharecombinant hepatitis B vaccine in a previous clinical study 4 years before, we measured the titre of anti-HBs. All, but one of the evaluated volunteers rem...

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Bibliographic Details
Published in:Vaccine 2003-10, Vol.21 (27-30), p.4481
Main Authors: Lepetic, A, Biscayart, C, Seigelchifer, M, Arduino, R, Stamboulian, D
Format: Article
Language:English
Subjects:
Antigens
Consent
Diabetes
Gene expression
Hepatitis
Immune response
Immunization
Infections
Laboratories
Proteins
Statistical analysis
Vaccines
Volunteers
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Summary:To evaluate the persistence of the immune response in a population of healthy volunteers that had been vaccinated with a newHansenula polymorpharecombinant hepatitis B vaccine in a previous clinical study 4 years before, we measured the titre of anti-HBs. All, but one of the evaluated volunteers remained protected. None of them had experienced any adverse event related to the vaccine from the moment of immunization, to the present. The vaccine proved to be immunogenic and to confer long-term protection in this group.
ISSN:0264-410X
1873-2518
DOI:10.1016/S0264-410X(03)00306-2