The Common Beta Chain Phosphorylation Axis Controls IL-5 Receptor Sub-cellular Distribution

Mutation of betaC Y-612 to phenylalanine (which is a STAT5 and SHP2 binding site) significantly altered the sub-cellular distribution and degradation rate of activated IL-5Rs.

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Bibliographic Details
Published in:Journal of allergy and clinical immunology 2011-02, Vol.127 (2), p.AB165-AB165
Main Authors: Martinez-Moczygemba, M, Lei, J.T, Mazumdar, T
Format: Article
Language:English
Subjects:
Allergy and Immunology
Kinases
Phosphorylation
Online Access:Get full text
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Description
Summary:Mutation of betaC Y-612 to phenylalanine (which is a STAT5 and SHP2 binding site) significantly altered the sub-cellular distribution and degradation rate of activated IL-5Rs.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2010.12.655