Anaphylaxis caused by hidden soybean allergens in pillows

• Published in: Journal of allergy and clinical immunology 2013-01, Vol.131 (1), p.228-230
• Main Authors: Armentia, Alicia, MD, PhD, Pineda, Fernando, PharmD, PhD, Martín, Blanca, TEF, San Miguel, Angel, MD, PhD, Martín Gil, Francisco Javier, ChD, PhD, Puente, Yolanda, MD, PhD, de Lecea, Carlos, MD, PhD, Palacios, Ricardo, MD, PhD
• Format: Article
• Language: English
• Subjects: Aged; Allergens - immunology; Allergies; Allergy and Immunology; Anaphylaxis - diagnosis; Anaphylaxis - immunology; Antigens; Antigens, Plant - immunology; Bedding and Linens; Biological and medical sciences; Female; Food; Food allergies; Food Hypersensitivity - immunology; Fundamental and applied biological sciences. Psychology; Fundamental immunology; Glycine max - immunology; Humans; Immunoglobulin E - immunology; Immunopathology; Lipids; Male; Medical sciences; Middle Aged; Patients; Proteins; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis; Seeds; Skin Tests; Sleep; Soy products; Soybeans; Workers
• ISSN: 0091-6749; 1097-6825
• DOI: 10.1016/j.jaci.2012.09.012

Nano high-perfomance liquid chromatography mass spectrometry analysis showed the high-molecular-weight soybean storage proteins β-conglycinin (Gly m 5) and glycinin (Gly m 6) were the proteins that bound soy flake-processing worker IgE.3 Gly m 5 and Gly m 6 might be respiratory sensitizers in occupationally and nonoccupationally exposed workers. β-Conglycinin was isolated and purified, and the physicochemical and adhesive properties of its subunits (β and α'α) were characterized.3 Soy is also used in pharmaceutical products as soymorphins4 or drug excipients.2 The diagnostic workup for suspected soy allergy includes food allergy screening tests, responses to an elimination diet, and an oral food challenge.