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Microvascular Glycocalyx Dimension Estimated by Automated SDF Imaging is not Related to Cardiovascular Disease
Objective The EG regulates vascular homeostasis and has anti‐atherogenic properties. SDF imaging allows for noninvasive visualization of microvessels and automated estimation of EG dimensions. We aimed to assess whether microcirculatory EG dimension is related to cardiovascular disease. Methods Subl...
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| Published in: | Microcirculation (New York, N.Y. 1994) N.Y. 1994), 2014-08, Vol.21 (6), p.499-505 |
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| Main Authors: | , , , , , |
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| container_end_page | 505 |
| container_issue | 6 |
| container_start_page | 499 |
| container_title | Microcirculation (New York, N.Y. 1994) |
| container_volume | 21 |
| creator | Amraoui, Fouad Olde Engberink, Rik H. G. van Gorp, Jacqueline Ramdani, Amal Vogt, Liffert van den Born, Bert-Jan H. |
| description | Objective
The EG regulates vascular homeostasis and has anti‐atherogenic properties. SDF imaging allows for noninvasive visualization of microvessels and automated estimation of EG dimensions. We aimed to assess whether microcirculatory EG dimension is related to cardiovascular disease.
Methods
Sublingual EG dimension was estimated by SDF imaging in healthy volunteers and in patients visiting an outpatient clinic for vascular medicine of a university hospital in Amsterdam, the Netherlands. EG dimension was compared among healthy volunteers, patients with CVD, and patients at low ( |
| doi_str_mv | 10.1111/micc.12125 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_1551386810</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3393714271</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3625-94c0ae6178adafe9af507749cc2a4b4717ac5b8f2a68d0006b3269e77c6a14a33</originalsourceid><addsrcrecordid>eNp9kMtO3TAURS1EBRQ66QdUlpghhdpJ_BqiXEivBEXiVWbWieMg0zzATij5-xoCdFZPbMvrbGsvhL5Sckjj-t45Yw5pSlO2gXYoy1UiBVWb8UxEligu5Tb6HMI9IUTKVG2h7TRnUlHGdlB_5owfniCYqQWPy3Y2g4F2fsYr19k-uKHHx2F0HYy2xtWMj6ZxWC6XqxO87uDO9XfYBdwPI76w7evTOOACfO3-Ba9csBDsHvrUQBvsl7d9F12fHF8VP5LT83JdHJ0mJuMpS1RuCFhOhYQaGqugYUSIXBmTQl7lggowrJJNClzWsRavspQrK4ThQHPIsl20v-Q--OFxsmHU98Pk-_iljrVpJrmkJFIHCxUVhOBtox98bOpnTYl-Uatf1OpXtRH-9hY5VZ2tP9B3lxGgC_DHtXb-T5Q-WxfFe2iyzLgw2uePGfC_NReZYPrXz1JflDfktlzdapH9BZzkk2w</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1551386810</pqid></control><display><type>article</type><title>Microvascular Glycocalyx Dimension Estimated by Automated SDF Imaging is not Related to Cardiovascular Disease</title><source>Wiley</source><creator>Amraoui, Fouad ; Olde Engberink, Rik H. G. ; van Gorp, Jacqueline ; Ramdani, Amal ; Vogt, Liffert ; van den Born, Bert-Jan H.</creator><creatorcontrib>Amraoui, Fouad ; Olde Engberink, Rik H. G. ; van Gorp, Jacqueline ; Ramdani, Amal ; Vogt, Liffert ; van den Born, Bert-Jan H.</creatorcontrib><description>Objective
The EG regulates vascular homeostasis and has anti‐atherogenic properties. SDF imaging allows for noninvasive visualization of microvessels and automated estimation of EG dimensions. We aimed to assess whether microcirculatory EG dimension is related to cardiovascular disease.
Methods
Sublingual EG dimension was estimated by SDF imaging in healthy volunteers and in patients visiting an outpatient clinic for vascular medicine of a university hospital in Amsterdam, the Netherlands. EG dimension was compared among healthy volunteers, patients with CVD, and patients at low (<10%) or high risk (≥10%) of CVD according to the Framingham algorithm.
Results
In total 120 patients and 30 healthy volunteers were included. Patients had a mean age of 59 ± 14 years, 71 (59%) were men and 24 (20%) were black. Healthy volunteers were on average 28 ± 4 years and 19 (63%) were men. EG dimension was similar in healthy volunteers (2.04 ± 0.23 μm), low‐risk patients (2.05 ± 0.24 μm, n = 39), high‐risk patients (2.05 ± 0.23 μm, n = 30) and in patients with CVD (2.09 ± 0.21 μm, n = 51, p = 0.79). EG dimension was not correlated with cardiovascular risk factors.
Conclusions
Microcirculatory EG dimension, as estimated by automated SDF imaging, is not associated with CVD, suggesting that this technique may not contribute to cardiovascular risk stratification.</description><identifier>ISSN: 1073-9688</identifier><identifier>EISSN: 1549-8719</identifier><identifier>DOI: 10.1111/micc.12125</identifier><identifier>PMID: 24589155</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Adult ; Aged ; Angiography ; Automation ; Cardiovascular disease ; Cardiovascular Diseases - metabolism ; Cardiovascular Diseases - pathology ; Cardiovascular Diseases - physiopathology ; Female ; glycocalyx ; Glycocalyx - metabolism ; Glycocalyx - pathology ; Health risk assessment ; Humans ; imaging ; Male ; Medical research ; Microcirculation ; Microscopy, Video ; Middle Aged ; Mouth Floor - blood supply ; Mouth Floor - metabolism ; Mouth Floor - pathology ; noninvasive</subject><ispartof>Microcirculation (New York, N.Y. 1994), 2014-08, Vol.21 (6), p.499-505</ispartof><rights>2014 John Wiley & Sons Ltd</rights><rights>2014 John Wiley & Sons Ltd.</rights><rights>Copyright © 2014 John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3625-94c0ae6178adafe9af507749cc2a4b4717ac5b8f2a68d0006b3269e77c6a14a33</citedby><cites>FETCH-LOGICAL-c3625-94c0ae6178adafe9af507749cc2a4b4717ac5b8f2a68d0006b3269e77c6a14a33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24589155$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Amraoui, Fouad</creatorcontrib><creatorcontrib>Olde Engberink, Rik H. G.</creatorcontrib><creatorcontrib>van Gorp, Jacqueline</creatorcontrib><creatorcontrib>Ramdani, Amal</creatorcontrib><creatorcontrib>Vogt, Liffert</creatorcontrib><creatorcontrib>van den Born, Bert-Jan H.</creatorcontrib><title>Microvascular Glycocalyx Dimension Estimated by Automated SDF Imaging is not Related to Cardiovascular Disease</title><title>Microcirculation (New York, N.Y. 1994)</title><addtitle>Microcirculation</addtitle><description>Objective
The EG regulates vascular homeostasis and has anti‐atherogenic properties. SDF imaging allows for noninvasive visualization of microvessels and automated estimation of EG dimensions. We aimed to assess whether microcirculatory EG dimension is related to cardiovascular disease.
Methods
Sublingual EG dimension was estimated by SDF imaging in healthy volunteers and in patients visiting an outpatient clinic for vascular medicine of a university hospital in Amsterdam, the Netherlands. EG dimension was compared among healthy volunteers, patients with CVD, and patients at low (<10%) or high risk (≥10%) of CVD according to the Framingham algorithm.
Results
In total 120 patients and 30 healthy volunteers were included. Patients had a mean age of 59 ± 14 years, 71 (59%) were men and 24 (20%) were black. Healthy volunteers were on average 28 ± 4 years and 19 (63%) were men. EG dimension was similar in healthy volunteers (2.04 ± 0.23 μm), low‐risk patients (2.05 ± 0.24 μm, n = 39), high‐risk patients (2.05 ± 0.23 μm, n = 30) and in patients with CVD (2.09 ± 0.21 μm, n = 51, p = 0.79). EG dimension was not correlated with cardiovascular risk factors.
Conclusions
Microcirculatory EG dimension, as estimated by automated SDF imaging, is not associated with CVD, suggesting that this technique may not contribute to cardiovascular risk stratification.</description><subject>Adult</subject><subject>Aged</subject><subject>Angiography</subject><subject>Automation</subject><subject>Cardiovascular disease</subject><subject>Cardiovascular Diseases - metabolism</subject><subject>Cardiovascular Diseases - pathology</subject><subject>Cardiovascular Diseases - physiopathology</subject><subject>Female</subject><subject>glycocalyx</subject><subject>Glycocalyx - metabolism</subject><subject>Glycocalyx - pathology</subject><subject>Health risk assessment</subject><subject>Humans</subject><subject>imaging</subject><subject>Male</subject><subject>Medical research</subject><subject>Microcirculation</subject><subject>Microscopy, Video</subject><subject>Middle Aged</subject><subject>Mouth Floor - blood supply</subject><subject>Mouth Floor - metabolism</subject><subject>Mouth Floor - pathology</subject><subject>noninvasive</subject><issn>1073-9688</issn><issn>1549-8719</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><recordid>eNp9kMtO3TAURS1EBRQ66QdUlpghhdpJ_BqiXEivBEXiVWbWieMg0zzATij5-xoCdFZPbMvrbGsvhL5Sckjj-t45Yw5pSlO2gXYoy1UiBVWb8UxEligu5Tb6HMI9IUTKVG2h7TRnUlHGdlB_5owfniCYqQWPy3Y2g4F2fsYr19k-uKHHx2F0HYy2xtWMj6ZxWC6XqxO87uDO9XfYBdwPI76w7evTOOACfO3-Ba9csBDsHvrUQBvsl7d9F12fHF8VP5LT83JdHJ0mJuMpS1RuCFhOhYQaGqugYUSIXBmTQl7lggowrJJNClzWsRavspQrK4ThQHPIsl20v-Q--OFxsmHU98Pk-_iljrVpJrmkJFIHCxUVhOBtox98bOpnTYl-Uatf1OpXtRH-9hY5VZ2tP9B3lxGgC_DHtXb-T5Q-WxfFe2iyzLgw2uePGfC_NReZYPrXz1JflDfktlzdapH9BZzkk2w</recordid><startdate>201408</startdate><enddate>201408</enddate><creator>Amraoui, Fouad</creator><creator>Olde Engberink, Rik H. G.</creator><creator>van Gorp, Jacqueline</creator><creator>Ramdani, Amal</creator><creator>Vogt, Liffert</creator><creator>van den Born, Bert-Jan H.</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope></search><sort><creationdate>201408</creationdate><title>Microvascular Glycocalyx Dimension Estimated by Automated SDF Imaging is not Related to Cardiovascular Disease</title><author>Amraoui, Fouad ; Olde Engberink, Rik H. G. ; van Gorp, Jacqueline ; Ramdani, Amal ; Vogt, Liffert ; van den Born, Bert-Jan H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3625-94c0ae6178adafe9af507749cc2a4b4717ac5b8f2a68d0006b3269e77c6a14a33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Angiography</topic><topic>Automation</topic><topic>Cardiovascular disease</topic><topic>Cardiovascular Diseases - metabolism</topic><topic>Cardiovascular Diseases - pathology</topic><topic>Cardiovascular Diseases - physiopathology</topic><topic>Female</topic><topic>glycocalyx</topic><topic>Glycocalyx - metabolism</topic><topic>Glycocalyx - pathology</topic><topic>Health risk assessment</topic><topic>Humans</topic><topic>imaging</topic><topic>Male</topic><topic>Medical research</topic><topic>Microcirculation</topic><topic>Microscopy, Video</topic><topic>Middle Aged</topic><topic>Mouth Floor - blood supply</topic><topic>Mouth Floor - metabolism</topic><topic>Mouth Floor - pathology</topic><topic>noninvasive</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Amraoui, Fouad</creatorcontrib><creatorcontrib>Olde Engberink, Rik H. G.</creatorcontrib><creatorcontrib>van Gorp, Jacqueline</creatorcontrib><creatorcontrib>Ramdani, Amal</creatorcontrib><creatorcontrib>Vogt, Liffert</creatorcontrib><creatorcontrib>van den Born, Bert-Jan H.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><jtitle>Microcirculation (New York, N.Y. 1994)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Amraoui, Fouad</au><au>Olde Engberink, Rik H. G.</au><au>van Gorp, Jacqueline</au><au>Ramdani, Amal</au><au>Vogt, Liffert</au><au>van den Born, Bert-Jan H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Microvascular Glycocalyx Dimension Estimated by Automated SDF Imaging is not Related to Cardiovascular Disease</atitle><jtitle>Microcirculation (New York, N.Y. 1994)</jtitle><addtitle>Microcirculation</addtitle><date>2014-08</date><risdate>2014</risdate><volume>21</volume><issue>6</issue><spage>499</spage><epage>505</epage><pages>499-505</pages><issn>1073-9688</issn><eissn>1549-8719</eissn><abstract>Objective
The EG regulates vascular homeostasis and has anti‐atherogenic properties. SDF imaging allows for noninvasive visualization of microvessels and automated estimation of EG dimensions. We aimed to assess whether microcirculatory EG dimension is related to cardiovascular disease.
Methods
Sublingual EG dimension was estimated by SDF imaging in healthy volunteers and in patients visiting an outpatient clinic for vascular medicine of a university hospital in Amsterdam, the Netherlands. EG dimension was compared among healthy volunteers, patients with CVD, and patients at low (<10%) or high risk (≥10%) of CVD according to the Framingham algorithm.
Results
In total 120 patients and 30 healthy volunteers were included. Patients had a mean age of 59 ± 14 years, 71 (59%) were men and 24 (20%) were black. Healthy volunteers were on average 28 ± 4 years and 19 (63%) were men. EG dimension was similar in healthy volunteers (2.04 ± 0.23 μm), low‐risk patients (2.05 ± 0.24 μm, n = 39), high‐risk patients (2.05 ± 0.23 μm, n = 30) and in patients with CVD (2.09 ± 0.21 μm, n = 51, p = 0.79). EG dimension was not correlated with cardiovascular risk factors.
Conclusions
Microcirculatory EG dimension, as estimated by automated SDF imaging, is not associated with CVD, suggesting that this technique may not contribute to cardiovascular risk stratification.</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>24589155</pmid><doi>10.1111/micc.12125</doi><tpages>7</tpages></addata></record> |
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| subjects | Adult Aged Angiography Automation Cardiovascular disease Cardiovascular Diseases - metabolism Cardiovascular Diseases - pathology Cardiovascular Diseases - physiopathology Female glycocalyx Glycocalyx - metabolism Glycocalyx - pathology Health risk assessment Humans imaging Male Medical research Microcirculation Microscopy, Video Middle Aged Mouth Floor - blood supply Mouth Floor - metabolism Mouth Floor - pathology noninvasive |
| title | Microvascular Glycocalyx Dimension Estimated by Automated SDF Imaging is not Related to Cardiovascular Disease |
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