NLRP3 and IL-1[beta] in macrophages as critical regulators of metabolic diseases

The activation of the NLRP3 inflammasome leads to the autocleavage and activation of caspase-1. Caspase-1 cleaves several substrates, including the pro-inflammatory cytokine IL-1[beta]. Inflammation, in particular IL-1[beta], has long been associated with the progression of metabolic disorders, and...

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Bibliographic Details
Published in:Diabetes, obesity & metabolism obesity & metabolism, 2013-09, Vol.15 (s3), p.19
Main Authors: McGettrick, A F, O'Neill, L A J
Format: Article
Language:English
Subjects:
Metabolic disorders
Online Access:Get full text
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Summary:The activation of the NLRP3 inflammasome leads to the autocleavage and activation of caspase-1. Caspase-1 cleaves several substrates, including the pro-inflammatory cytokine IL-1[beta]. Inflammation, in particular IL-1[beta], has long been associated with the progression of metabolic disorders, and recent evidence suggests that the NLRP3 inflammasome plays a critical role in this inflammation. This review concentrates on the activation of NLRP3 during the development of metabolic disorders and the effect this activation has on the inflammatory state as well as the metabolic state of the cell. [PUBLICATION ABSTRACT]
ISSN:1462-8902
1463-1326
DOI:10.1111/dom.12169