Generation of Dipeptidyl Peptidase-IV-Inhibiting Peptides from [beta]-Lactoglobulin Secreted by Lactococcus lactis

Previous studies showed that hydrolysates of β-lactoglobulin (BLG) prepared using gastrointestinal proteases strongly inhibit dipeptidyl peptidase-IV (DPP-IV) activity in vitro. In this study, we developed a BLG-secreting Lactococcus lactis strain as a delivery vehicle and in situ expression system....

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Bibliographic Details
Published in:BioMed research international 2014-01, Vol.2014
Main Authors: Shigemori, Suguru, Oshiro, Kazushi, Wang, Pengfei, Yamamoto, Yoshinari, Wang, Yeqin, Sato, Takashi, Uyeno, Yutaka, Shimosato, Takeshi
Format: Article
Language:English
Subjects:
Binding sites
Cloning
Genes
Peptides
Proteins
Science
Studies
Vaccines
Online Access:Get full text
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Summary:Previous studies showed that hydrolysates of β-lactoglobulin (BLG) prepared using gastrointestinal proteases strongly inhibit dipeptidyl peptidase-IV (DPP-IV) activity in vitro. In this study, we developed a BLG-secreting Lactococcus lactis strain as a delivery vehicle and in situ expression system. Interestingly, trypsin-digested recombinant BLG from L. lactis inhibited DPP-IV activity, suggesting that BLG-secreting L. lactis may be useful in the treatment of type 2 diabetes mellitus.
ISSN:2314-6133
2314-6141
DOI:10.1155/2014/393598