Genome-wide association study identifies new susceptibility loci for epithelial ovarian cancer in Han Chinese women

Ovarian cancer is the leading cause of death from gynaecological malignancies worldwide. Here we perform a three-stage genome-wide association study (GWAS) in Han Chinese women to identify risk genetic variants for epithelial ovarian cancer (EOC). We scan 900,015 single-nucleotide polymorphisms (SNP...

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Bibliographic Details
Published in:Nature communications 2014-08, Vol.5 (1), p.4682, Article 4682
Main Authors: Chen, Kexin, Ma, Hongxia, Li, Lian, Zang, Rongyu, Wang, Cheng, Song, Fengju, Shi, Tingyan, Yu, Dianke, Yang, Ming, Xue, Wenqiong, Dai, Juncheng, Li, Shuang, Zheng, Hong, Wu, Chen, Zhang, Ying, Wu, Xiaohua, Li, Dake, Xue, Fengxia, Li, Haixin, Jiang, Zhi, Liu, Jibin, Liu, Yuexin, Li, Pei, Tan, Wen, Han, Jing, Jie, Jiang, Hao, Quan, Hu, Zhibin, Lin, Dongxin, Ma, Ding, Jia, Weihua, Shen, Hongbing, Wei, Qingyi
Format: Article
Language:English
Subjects:
45/43
631/208/205/2138
692/420/2489/68
692/699/67/1517/1709
Adult
Asian Continental Ancestry Group - genetics
Carcinoma, Ovarian Epithelial
Case-Control Studies
Collagen - genetics
Female
Genetic Loci - genetics
Genetic Predisposition to Disease - ethnology
Genetic Predisposition to Disease - genetics
Genome-Wide Association Study
GTPase-Activating Proteins - genetics
Humanities and Social Sciences
Humans
Middle Aged
multidisciplinary
Neoplasms, Glandular and Epithelial - ethnology
Neoplasms, Glandular and Epithelial - genetics
Nuclear Proteins - genetics
Ovarian Neoplasms - ethnology
Ovarian Neoplasms - genetics
Polymorphism, Single Nucleotide - genetics
Protein-Serine-Threonine Kinases - genetics
Risk Factors
Science
Science (multidisciplinary)
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Summary:Ovarian cancer is the leading cause of death from gynaecological malignancies worldwide. Here we perform a three-stage genome-wide association study (GWAS) in Han Chinese women to identify risk genetic variants for epithelial ovarian cancer (EOC). We scan 900,015 single-nucleotide polymorphisms (SNPs) in 1,057 EOC cases and 1,191 controls in stage I, and replicate 41 SNPs ( P meta
ISSN:2041-1723
2041-1723
DOI:10.1038/ncomms5682