Improved outcome after primary vitrectomy in diabetic patients treated with simvastatin

Purpose Simvastatin treatment may reduce intravitreal levels of potent vasoactive, angiogenic, and fibroproliferative factors. Here, we evaluated the effect of preoperative simvastatin treatment on the outcome of primary vitrectomy in diabetic patients. Methods Prospective, observational case contro...

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Bibliographic Details
Published in:Acta ophthalmologica (Oxford, England) England), 2014-09, Vol.92 (s253), p.0-0
Main Authors: LOUKOVAARA, S, SAHANNE, S, TUUMINEN, R
Format: Article
Language:English
Subjects:
Cholesterol
Diabetes
Diabetic retinopathy
Ophthalmology
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Summary:Purpose Simvastatin treatment may reduce intravitreal levels of potent vasoactive, angiogenic, and fibroproliferative factors. Here, we evaluated the effect of preoperative simvastatin treatment on the outcome of primary vitrectomy in diabetic patients. Methods Prospective, observational case control study of type 1 and 2 adult diabetic patients admitted for primary vitrectomy in management of sight‐threatening forms of diabetic retinopathy (DR). A 1‐month best corrected visual acuity (BCVA) gain and cumulative 12‐month re‐vitrectomy frequency of 192 diabetic patients, 79 on simvastatin treatment and 113 without any statin medication. Results Diabetic patients with simvastatin treatment had a better 1‐month BCVA improvement than did those without statin treatment (p=0.009). Subgroup analysis revealed that diabetics on simvastatin had better post‐operative BCVA improvement when preoperative status included partial or panretinal laser photocoagulation (p=0.042 and p=0.049) and anti‐VEGF therapy (p=0.011). Moreover, diabetics pre‐operatively with macular edema (p=0.009), vitreous hemorrhage (p
ISSN:1755-375X
1755-3768
DOI:10.1111/j.1755-3768.2014.4476.x