Enhanced proliferation in colorectal epithelium of patients with type 2 diabetes correlates with [beta]-catenin accumulation

Aims β-Catenin accumulation promotes proliferation. However, the correlation between proliferation of colorectal epithelium and β-catenin in type 2 diabetes mellitus (DM) patients remains unclear. Methods Colorectal epithelium samples from distal ends of colorectal adenocarcinomas without histologic...

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Bibliographic Details
Published in:Journal of diabetes and its complications 2014-09, Vol.28 (5), p.689
Main Authors: Li, Jie-Yao, Yu, Tao, Xia, Zhong-Sheng, Chen, Guang-Cheng, Yuan, Yu-Hong, Zhong, Wa, Zhao, Li-Na, Chen, Qi-Kui
Format: Article
Language:English
Subjects:
Cell growth
Colorectal cancer
Cyclin-dependent kinases
Diabetes
Hyperglycemia
Kinases
Pathology
Phosphorylation
Rodents
Signal transduction
Stem cells
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Summary:Aims β-Catenin accumulation promotes proliferation. However, the correlation between proliferation of colorectal epithelium and β-catenin in type 2 diabetes mellitus (DM) patients remains unclear. Methods Colorectal epithelium samples from distal ends of colorectal adenocarcinomas without histological aberrances were divided into two groups: DM patients with type 2 DM for more than 1year (n=27) and non-DM patients without hyperglycemia (n=20). Samples from patients without colorectal epithelial disease or hyperglycemia served as a control group (n=6). Proliferative index was calculated as the percentage of proliferating cell nuclear antigen positive cells. Wnt/β-catenin signaling was assessed immunohistochemically and phosphorylation of β-catenin was assessed by immunofluorescence. Results Compared with the non-DM or control group, the proliferative index and expression of lactate dehydrogenase A and Wnt/β-catenin signaling were significantly higher in the DM group (allp
ISSN:1056-8727
1873-460X
DOI:10.1016/j.jdiacomp.2014.05.001