Sunitinib Does not Attenuate Contractile Force at Therapeutic Concentrations Following a Period of Ischemia in Isolated Human Cardiac Muscle

Introduction Patients treated for cancer with the tyrosine kinase inhibitor sunitinib are at increased risk for development of heart failure, particularly those with previous coronary artery disease and/or hypertension. [...]we studied the effect of sunitinib on the contractility of isolated human a...

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Bibliographic Details
Published in:Clinical therapeutics 2014-08, Vol.36 (8), p.e13-e14
Main Authors: Thijs, A.M, Vos, A, Wouterse, A, El Messaoudi, S, van Swieten, H, Verweij, V, Herpen, C.M, van der Graaf, W.T.A, Noyez, L, Rongen, G.A
Format: Article
Language:English
Subjects:
Cardiomyocytes
Cardiovascular disease
Heart failure
Internal Medicine
Ischemia
Medical Education
Medical treatment
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Summary:Introduction Patients treated for cancer with the tyrosine kinase inhibitor sunitinib are at increased risk for development of heart failure, particularly those with previous coronary artery disease and/or hypertension. [...]we studied the effect of sunitinib on the contractility of isolated human atrial trabeculae and the effect on recovery after ischemia.
ISSN:0149-2918
1879-114X
DOI:10.1016/j.clinthera.2014.05.053